Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial
The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. Fifteen healthy individuals (five females, age of 25.4 ± 2.5 years, BMI of 23.7 ± 1.7 kg/m<sup>2</sup> with...
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MDPI AG
2021
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oai:doaj.org-article:54dc07e4497f413c9d05bfe22bc5ce2c2021-11-25T18:36:43ZAcute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial10.3390/nu131140952072-6643https://doaj.org/article/54dc07e4497f413c9d05bfe22bc5ce2c2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4095https://doaj.org/toc/2072-6643The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. Fifteen healthy individuals (five females, age of 25.4 ± 2.5 years, BMI of 23.7 ± 1.7 kg/m<sup>2</sup> with a body mass (BM) of 76.3 ± 12.3 kg) participated in this double-blind randomized crossover placebo-controlled trial. Participants received a mixture of 300 mL of water with 1 g/kg BM of Glu, 1 g/kg BM of Fru, 0.5 g/kg BM of GluFru (each), and 0.2 g sucralose as a placebo. Peak BG values Glu were reached after 40 ± 13 min (peak BG: 141 ± 20 mg/dL), for Fru after 36 ± 22 min (peak BG: 98 ± 7 mg/dL), for GluFru after 29 ± 8 min (BG 128 ± 18 mg/dL), and sucralose after 34 ± 27 min (peak BG: 83 ± 5 mg/dL). Significant differences regarding the time until peak BG were found only between Glu and GluFru supplementation (<i>p</i> = 0.02). Peak blood glucose levels were significantly lower following the ingestion of Fru compared to the supplementation of Glu and GluFru (<i>p</i> < 0.0001) while Glu and GluFru supplementation showed no difference in peak values (<i>p</i> = 0.23). All conditions led to a significantly higher peak BG value compared to sucralose (<i>p</i> < 0.0001). Blood lactate increased in Glu (<i>p</i> = 0.002), Fru and GluFru (both <i>p</i> < 0.0001), whereas sucralose did not increase compared to the baseline (<i>p</i> = 0.051). Insulin levels were significantly higher in all conditions at peak compared to sucralose (<i>p</i> < 0.0001). The findings of this study prove the feasibility of combined carbohydrate supplementations for many applications in diabetic or healthy exercise cohorts.Max L. EcksteinAntonia BrockfeldSandra HauptJanis R. SchierbauerRebecca T. ZimmerNadine WachsmuthBeate ZunnerPaul ZimmermannBarbara Obermayer-PietschOthmar MoserMDPI AGarticleglucosemetabolismfructosesucralosehealthy individualsinsulinNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4095, p 4095 (2021) |
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| collection |
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| topic |
glucose metabolism fructose sucralose healthy individuals insulin Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
glucose metabolism fructose sucralose healthy individuals insulin Nutrition. Foods and food supply TX341-641 Max L. Eckstein Antonia Brockfeld Sandra Haupt Janis R. Schierbauer Rebecca T. Zimmer Nadine Wachsmuth Beate Zunner Paul Zimmermann Barbara Obermayer-Pietsch Othmar Moser Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| description |
The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. Fifteen healthy individuals (five females, age of 25.4 ± 2.5 years, BMI of 23.7 ± 1.7 kg/m<sup>2</sup> with a body mass (BM) of 76.3 ± 12.3 kg) participated in this double-blind randomized crossover placebo-controlled trial. Participants received a mixture of 300 mL of water with 1 g/kg BM of Glu, 1 g/kg BM of Fru, 0.5 g/kg BM of GluFru (each), and 0.2 g sucralose as a placebo. Peak BG values Glu were reached after 40 ± 13 min (peak BG: 141 ± 20 mg/dL), for Fru after 36 ± 22 min (peak BG: 98 ± 7 mg/dL), for GluFru after 29 ± 8 min (BG 128 ± 18 mg/dL), and sucralose after 34 ± 27 min (peak BG: 83 ± 5 mg/dL). Significant differences regarding the time until peak BG were found only between Glu and GluFru supplementation (<i>p</i> = 0.02). Peak blood glucose levels were significantly lower following the ingestion of Fru compared to the supplementation of Glu and GluFru (<i>p</i> < 0.0001) while Glu and GluFru supplementation showed no difference in peak values (<i>p</i> = 0.23). All conditions led to a significantly higher peak BG value compared to sucralose (<i>p</i> < 0.0001). Blood lactate increased in Glu (<i>p</i> = 0.002), Fru and GluFru (both <i>p</i> < 0.0001), whereas sucralose did not increase compared to the baseline (<i>p</i> = 0.051). Insulin levels were significantly higher in all conditions at peak compared to sucralose (<i>p</i> < 0.0001). The findings of this study prove the feasibility of combined carbohydrate supplementations for many applications in diabetic or healthy exercise cohorts. |
| format |
article |
| author |
Max L. Eckstein Antonia Brockfeld Sandra Haupt Janis R. Schierbauer Rebecca T. Zimmer Nadine Wachsmuth Beate Zunner Paul Zimmermann Barbara Obermayer-Pietsch Othmar Moser |
| author_facet |
Max L. Eckstein Antonia Brockfeld Sandra Haupt Janis R. Schierbauer Rebecca T. Zimmer Nadine Wachsmuth Beate Zunner Paul Zimmermann Barbara Obermayer-Pietsch Othmar Moser |
| author_sort |
Max L. Eckstein |
| title |
Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_short |
Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_full |
Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_fullStr |
Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_full_unstemmed |
Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_sort |
acute metabolic responses to glucose and fructose supplementation in healthy individuals: a double-blind randomized crossover placebo-controlled trial |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/54dc07e4497f413c9d05bfe22bc5ce2c |
| work_keys_str_mv |
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