Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola

Tetrameric cationic channels specificity is determined by the sequence and structural conformation of their selectivity filter. Here, the authors show that a cationic channel from Tsukamurella paurometabola is non-selective due to a Ca2+-binding motif within its unusual proline-rich filter.

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Auteurs principaux:	Balasundaresan Dhakshnamoorthy, Ahmed Rohaim, Huan Rui, Lydia Blachowicz, Benoît Roux
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/54ddb1f1acfa493bbfb0cb50effbba4f
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spelling	oai:doaj.org-article:54ddb1f1acfa493bbfb0cb50effbba4f2021-12-02T15:34:54ZStructural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola10.1038/ncomms127532041-1723https://doaj.org/article/54ddb1f1acfa493bbfb0cb50effbba4f2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12753https://doaj.org/toc/2041-1723Tetrameric cationic channels specificity is determined by the sequence and structural conformation of their selectivity filter. Here, the authors show that a cationic channel from Tsukamurella paurometabola is non-selective due to a Ca2+-binding motif within its unusual proline-rich filter.Balasundaresan DhakshnamoorthyAhmed RohaimHuan RuiLydia BlachowiczBenoît RouxNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Balasundaresan Dhakshnamoorthy Ahmed Rohaim Huan Rui Lydia Blachowicz Benoît Roux Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
description	Tetrameric cationic channels specificity is determined by the sequence and structural conformation of their selectivity filter. Here, the authors show that a cationic channel from Tsukamurella paurometabola is non-selective due to a Ca2+-binding motif within its unusual proline-rich filter.
format	article
author	Balasundaresan Dhakshnamoorthy Ahmed Rohaim Huan Rui Lydia Blachowicz Benoît Roux
author_facet	Balasundaresan Dhakshnamoorthy Ahmed Rohaim Huan Rui Lydia Blachowicz Benoît Roux
author_sort	Balasundaresan Dhakshnamoorthy
title	Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
title_short	Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
title_full	Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
title_fullStr	Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
title_full_unstemmed	Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola
title_sort	structural and functional characterization of a calcium-activated cation channel from tsukamurella paurometabola
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/54ddb1f1acfa493bbfb0cb50effbba4f
work_keys_str_mv	AT balasundaresandhakshnamoorthy structuralandfunctionalcharacterizationofacalciumactivatedcationchannelfromtsukamurellapaurometabola AT ahmedrohaim structuralandfunctionalcharacterizationofacalciumactivatedcationchannelfromtsukamurellapaurometabola AT huanrui structuralandfunctionalcharacterizationofacalciumactivatedcationchannelfromtsukamurellapaurometabola AT lydiablachowicz structuralandfunctionalcharacterizationofacalciumactivatedcationchannelfromtsukamurellapaurometabola AT benoitroux structuralandfunctionalcharacterizationofacalciumactivatedcationchannelfromtsukamurellapaurometabola
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Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola

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