Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola

Tetrameric cationic channels specificity is determined by the sequence and structural conformation of their selectivity filter. Here, the authors show that a cationic channel from Tsukamurella paurometabola is non-selective due to a Ca2+-binding motif within its unusual proline-rich filter.

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Auteurs principaux: Balasundaresan Dhakshnamoorthy, Ahmed Rohaim, Huan Rui, Lydia Blachowicz, Benoît Roux
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/54ddb1f1acfa493bbfb0cb50effbba4f
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