Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators

Recent experimental work has revealed non-linear dendritic integration in interneurons. Here, the authors show, through detailed biophysical modeling, that fast spiking interneurons are better described with a 2-stage artificial neural network model calling into question the use of point neuron mode...

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Autores principales:	Alexandra Tzilivaki, George Kastellakis, Panayiota Poirazi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54e1f0705b4347339b0c67285006dbd5
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id	oai:doaj.org-article:54e1f0705b4347339b0c67285006dbd5
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spelling	oai:doaj.org-article:54e1f0705b4347339b0c67285006dbd52021-12-02T17:01:51ZChallenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators10.1038/s41467-019-11537-72041-1723https://doaj.org/article/54e1f0705b4347339b0c67285006dbd52019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11537-7https://doaj.org/toc/2041-1723Recent experimental work has revealed non-linear dendritic integration in interneurons. Here, the authors show, through detailed biophysical modeling, that fast spiking interneurons are better described with a 2-stage artificial neural network model calling into question the use of point neuron models.Alexandra TzilivakiGeorge KastellakisPanayiota PoiraziNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra Tzilivaki George Kastellakis Panayiota Poirazi Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators
description	Recent experimental work has revealed non-linear dendritic integration in interneurons. Here, the authors show, through detailed biophysical modeling, that fast spiking interneurons are better described with a 2-stage artificial neural network model calling into question the use of point neuron models.
format	article
author	Alexandra Tzilivaki George Kastellakis Panayiota Poirazi
author_facet	Alexandra Tzilivaki George Kastellakis Panayiota Poirazi
author_sort	Alexandra Tzilivaki
title	Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators
title_short	Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators
title_full	Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators
title_fullStr	Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators
title_full_unstemmed	Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators
title_sort	challenging the point neuron dogma: fs basket cells as 2-stage nonlinear integrators
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/54e1f0705b4347339b0c67285006dbd5
work_keys_str_mv	AT alexandratzilivaki challengingthepointneurondogmafsbasketcellsas2stagenonlinearintegrators AT georgekastellakis challengingthepointneurondogmafsbasketcellsas2stagenonlinearintegrators AT panayiotapoirazi challengingthepointneurondogmafsbasketcellsas2stagenonlinearintegrators
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Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators

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