Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs

Abstract Myocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way of preventing MI maybe by dietary supplements. The present study was thus designed to ascertain the cardio-protective effect of a formulated curcumin and nisin based poly lactic acid nanoparticle...

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Autores principales:	Williams E. E. Nabofa, Oluwadamilola O. Alashe, Oyetunde T. Oyeyemi, Alfred F. Attah, Ademola A. Oyagbemi, Temidayo O. Omobowale, Adeolu A. Adedapo, Akinola R. A. Alada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Cardio-protective Effects Isoproterenol (ISO) Cardiac troponin-I (CTnI) Curcumin Hypertrophy Index Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54e28163f3c14de0a0167238b0d3b516
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spelling	oai:doaj.org-article:54e28163f3c14de0a0167238b0d3b5162021-12-02T15:08:29ZCardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs10.1038/s41598-018-35145-52045-2322https://doaj.org/article/54e28163f3c14de0a0167238b0d3b5162018-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-35145-5https://doaj.org/toc/2045-2322Abstract Myocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way of preventing MI maybe by dietary supplements. The present study was thus designed to ascertain the cardio-protective effect of a formulated curcumin and nisin based poly lactic acid nanoparticle (CurNisNp) on isoproterenol (ISO) induced MI in guinea pigs. Animals were pretreated for 7 days as follows; Groups A and B animals were given 0.5 mL/kg of normal saline, group C metoprolol (2 mg/kg), groups D and E CurNisNp 10 and 21 mg/kg respectively (n = 5). MI was induced on the 7th day in groups B-E animals. On the 9th day electrocardiogram (ECG) was recorded, blood samples and tissue biopsies were collected for analyses. Toxicity studies on CurNisNp were carried out. MI induction caused atrial fibrillation which was prevented by pretreatment of metoprolol or CurNisNp. MI induction was also associated with increased expressions of cardiac troponin I (CTnI) and kidney injury molecule-1 (KIM-1) which were significantly reduced in guinea pig’s pretreated with metoprolol or CurNisNp (P < 0.05). The LC50 of CurNisNp was 3258.2 μg/mL. This study demonstrated that the formulated curcumin-nisin based nanoparticle confers a significant level of cardio-protection in the guinea pig and is nontoxic.Williams E. E. NabofaOluwadamilola O. AlasheOyetunde T. OyeyemiAlfred F. AttahAdemola A. OyagbemiTemidayo O. OmobowaleAdeolu A. AdedapoAkinola R. A. AladaNature PortfolioarticleCardio-protective EffectsIsoproterenol (ISO)Cardiac troponin-I (CTnI)CurcuminHypertrophy IndexMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardio-protective Effects Isoproterenol (ISO) Cardiac troponin-I (CTnI) Curcumin Hypertrophy Index Medicine R Science Q
spellingShingle	Cardio-protective Effects Isoproterenol (ISO) Cardiac troponin-I (CTnI) Curcumin Hypertrophy Index Medicine R Science Q Williams E. E. Nabofa Oluwadamilola O. Alashe Oyetunde T. Oyeyemi Alfred F. Attah Ademola A. Oyagbemi Temidayo O. Omobowale Adeolu A. Adedapo Akinola R. A. Alada Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
description	Abstract Myocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way of preventing MI maybe by dietary supplements. The present study was thus designed to ascertain the cardio-protective effect of a formulated curcumin and nisin based poly lactic acid nanoparticle (CurNisNp) on isoproterenol (ISO) induced MI in guinea pigs. Animals were pretreated for 7 days as follows; Groups A and B animals were given 0.5 mL/kg of normal saline, group C metoprolol (2 mg/kg), groups D and E CurNisNp 10 and 21 mg/kg respectively (n = 5). MI was induced on the 7th day in groups B-E animals. On the 9th day electrocardiogram (ECG) was recorded, blood samples and tissue biopsies were collected for analyses. Toxicity studies on CurNisNp were carried out. MI induction caused atrial fibrillation which was prevented by pretreatment of metoprolol or CurNisNp. MI induction was also associated with increased expressions of cardiac troponin I (CTnI) and kidney injury molecule-1 (KIM-1) which were significantly reduced in guinea pig’s pretreated with metoprolol or CurNisNp (P < 0.05). The LC50 of CurNisNp was 3258.2 μg/mL. This study demonstrated that the formulated curcumin-nisin based nanoparticle confers a significant level of cardio-protection in the guinea pig and is nontoxic.
format	article
author	Williams E. E. Nabofa Oluwadamilola O. Alashe Oyetunde T. Oyeyemi Alfred F. Attah Ademola A. Oyagbemi Temidayo O. Omobowale Adeolu A. Adedapo Akinola R. A. Alada
author_facet	Williams E. E. Nabofa Oluwadamilola O. Alashe Oyetunde T. Oyeyemi Alfred F. Attah Ademola A. Oyagbemi Temidayo O. Omobowale Adeolu A. Adedapo Akinola R. A. Alada
author_sort	Williams E. E. Nabofa
title	Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
title_short	Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
title_full	Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
title_fullStr	Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
title_full_unstemmed	Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
title_sort	cardioprotective effects of curcumin-nisin based poly lactic acid nanoparticle on myocardial infarction in guinea pigs
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/54e28163f3c14de0a0167238b0d3b516
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Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs

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