Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose phosphate pathway gene RPIA and that targeting...

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Autores principales:	Naiara Santana-Codina, Anjali A. Roeth, Yi Zhang, Annan Yang, Oksana Mashadova, John M. Asara, Xiaoxu Wang, Roderick T. Bronson, Costas A. Lyssiotis, Haoqiang Ying, Alec C. Kimmelman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54e4abc4188c4609baed834f3f363f66
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spelling	oai:doaj.org-article:54e4abc4188c4609baed834f3f363f662021-12-02T16:50:12ZOncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis10.1038/s41467-018-07472-82041-1723https://doaj.org/article/54e4abc4188c4609baed834f3f363f662018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07472-8https://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose phosphate pathway gene RPIA and that targeting nucleotide metabolism restore sensitivity to KRAS pathway inhibition.Naiara Santana-CodinaAnjali A. RoethYi ZhangAnnan YangOksana MashadovaJohn M. AsaraXiaoxu WangRoderick T. BronsonCostas A. LyssiotisHaoqiang YingAlec C. KimmelmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naiara Santana-Codina Anjali A. Roeth Yi Zhang Annan Yang Oksana Mashadova John M. Asara Xiaoxu Wang Roderick T. Bronson Costas A. Lyssiotis Haoqiang Ying Alec C. Kimmelman Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
description	Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose phosphate pathway gene RPIA and that targeting nucleotide metabolism restore sensitivity to KRAS pathway inhibition.
format	article
author	Naiara Santana-Codina Anjali A. Roeth Yi Zhang Annan Yang Oksana Mashadova John M. Asara Xiaoxu Wang Roderick T. Bronson Costas A. Lyssiotis Haoqiang Ying Alec C. Kimmelman
author_facet	Naiara Santana-Codina Anjali A. Roeth Yi Zhang Annan Yang Oksana Mashadova John M. Asara Xiaoxu Wang Roderick T. Bronson Costas A. Lyssiotis Haoqiang Ying Alec C. Kimmelman
author_sort	Naiara Santana-Codina
title	Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
title_short	Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
title_full	Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
title_fullStr	Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
title_full_unstemmed	Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
title_sort	oncogenic kras supports pancreatic cancer through regulation of nucleotide synthesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/54e4abc4188c4609baed834f3f363f66
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_version_	1718383098810335232

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

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