Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

While structural importance of linker histone H1 in packaging eukaryotic genome into chromatin is well known, its biological function remains poorly understood. Here the authors reveal that Drosophila linker histone H1 prevents DNA:RNA hybrids accumulation and genome instability in heterochromatin.

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Autores principales:	Aleix Bayona-Feliu, Anna Casas-Lamesa, Oscar Reina, Jordi Bernués, Fernando Azorín
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54e92716a1c5421ab62720cdc86bee36
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id	oai:doaj.org-article:54e92716a1c5421ab62720cdc86bee36
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spelling	oai:doaj.org-article:54e92716a1c5421ab62720cdc86bee362021-12-02T10:48:18ZLinker histone H1 prevents R-loop accumulation and genome instability in heterochromatin10.1038/s41467-017-00338-52041-1723https://doaj.org/article/54e92716a1c5421ab62720cdc86bee362017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00338-5https://doaj.org/toc/2041-1723While structural importance of linker histone H1 in packaging eukaryotic genome into chromatin is well known, its biological function remains poorly understood. Here the authors reveal that Drosophila linker histone H1 prevents DNA:RNA hybrids accumulation and genome instability in heterochromatin.Aleix Bayona-FeliuAnna Casas-LamesaOscar ReinaJordi BernuésFernando AzorínNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aleix Bayona-Feliu Anna Casas-Lamesa Oscar Reina Jordi Bernués Fernando Azorín Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
description	While structural importance of linker histone H1 in packaging eukaryotic genome into chromatin is well known, its biological function remains poorly understood. Here the authors reveal that Drosophila linker histone H1 prevents DNA:RNA hybrids accumulation and genome instability in heterochromatin.
format	article
author	Aleix Bayona-Feliu Anna Casas-Lamesa Oscar Reina Jordi Bernués Fernando Azorín
author_facet	Aleix Bayona-Feliu Anna Casas-Lamesa Oscar Reina Jordi Bernués Fernando Azorín
author_sort	Aleix Bayona-Feliu
title	Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
title_short	Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
title_full	Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
title_fullStr	Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
title_full_unstemmed	Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
title_sort	linker histone h1 prevents r-loop accumulation and genome instability in heterochromatin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/54e92716a1c5421ab62720cdc86bee36
work_keys_str_mv	AT aleixbayonafeliu linkerhistoneh1preventsrloopaccumulationandgenomeinstabilityinheterochromatin AT annacasaslamesa linkerhistoneh1preventsrloopaccumulationandgenomeinstabilityinheterochromatin AT oscarreina linkerhistoneh1preventsrloopaccumulationandgenomeinstabilityinheterochromatin AT jordibernues linkerhistoneh1preventsrloopaccumulationandgenomeinstabilityinheterochromatin AT fernandoazorin linkerhistoneh1preventsrloopaccumulationandgenomeinstabilityinheterochromatin
_version_	1718396646094536704

Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

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