Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

While structural importance of linker histone H1 in packaging eukaryotic genome into chromatin is well known, its biological function remains poorly understood. Here the authors reveal that Drosophila linker histone H1 prevents DNA:RNA hybrids accumulation and genome instability in heterochromatin.

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Autores principales: Aleix Bayona-Feliu, Anna Casas-Lamesa, Oscar Reina, Jordi Bernués, Fernando Azorín
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/54e92716a1c5421ab62720cdc86bee36
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