Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

Yang et al find that phase separation of the Epstein-Barr virus nuclear antigen 2 (EBNA2) is involved in the formation of accessible chromatin domains of the host genome. They also find that EBNA2 recruits histone acetyltransferase to promote histone acetylation on accessible chromatin regions and r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yiting Yang, Xidong Ye, Ranran Dai, Zhaoqiang Li, Yan Zhang, Wei Xue, Yongchang Zhu, Delong Feng, Litao Qin, Xin Wang, Bo Lei, Shixiu Liao, Bingtao Hao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/54eb75185baa492988225a9b7deef042
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54eb75185baa492988225a9b7deef042
record_format	dspace
spelling	oai:doaj.org-article:54eb75185baa492988225a9b7deef0422021-12-02T18:51:45ZPhase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation10.1038/s42003-021-02501-72399-3642https://doaj.org/article/54eb75185baa492988225a9b7deef0422021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02501-7https://doaj.org/toc/2399-3642Yang et al find that phase separation of the Epstein-Barr virus nuclear antigen 2 (EBNA2) is involved in the formation of accessible chromatin domains of the host genome. They also find that EBNA2 recruits histone acetyltransferase to promote histone acetylation on accessible chromatin regions and regulate gene expression and that these two functions are performed by the N- and Cterminus respectively.Yiting YangXidong YeRanran DaiZhaoqiang LiYan ZhangWei XueYongchang ZhuDelong FengLitao QinXin WangBo LeiShixiu LiaoBingtao HaoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yiting Yang Xidong Ye Ranran Dai Zhaoqiang Li Yan Zhang Wei Xue Yongchang Zhu Delong Feng Litao Qin Xin Wang Bo Lei Shixiu Liao Bingtao Hao Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
description	Yang et al find that phase separation of the Epstein-Barr virus nuclear antigen 2 (EBNA2) is involved in the formation of accessible chromatin domains of the host genome. They also find that EBNA2 recruits histone acetyltransferase to promote histone acetylation on accessible chromatin regions and regulate gene expression and that these two functions are performed by the N- and Cterminus respectively.
format	article
author	Yiting Yang Xidong Ye Ranran Dai Zhaoqiang Li Yan Zhang Wei Xue Yongchang Zhu Delong Feng Litao Qin Xin Wang Bo Lei Shixiu Liao Bingtao Hao
author_facet	Yiting Yang Xidong Ye Ranran Dai Zhaoqiang Li Yan Zhang Wei Xue Yongchang Zhu Delong Feng Litao Qin Xin Wang Bo Lei Shixiu Liao Bingtao Hao
author_sort	Yiting Yang
title	Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
title_short	Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
title_full	Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
title_fullStr	Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
title_full_unstemmed	Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
title_sort	phase separation of epstein-barr virus ebna2 protein reorganizes chromatin topology for epigenetic regulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54eb75185baa492988225a9b7deef042
work_keys_str_mv	AT yitingyang phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT xidongye phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT ranrandai phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT zhaoqiangli phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT yanzhang phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT weixue phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT yongchangzhu phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT delongfeng phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT litaoqin phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT xinwang phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT bolei phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT shixiuliao phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation AT bingtaohao phaseseparationofepsteinbarrvirusebna2proteinreorganizeschromatintopologyforepigeneticregulation
_version_	1718377385401778176

Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

Ejemplares similares