Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.

<h4>Background</h4>Hyperthyroidism has been linked with different morbidities, like atrial fibrillation, stroke and diabetes mellitus. However, our knowledge regarding the extent and temporal relation between hyperthyroidism and other diseases is fragmented. Here, we aimed at evaluating...

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Autores principales:	Frans Brandt, Marianne Thvilum, Dorthe Almind, Kaare Christensen, Anders Green, Laszlo Hegedüs, Thomas Heiberg Brix
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54ec88cc489e422c8098fe2eb7739a0d
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spelling	oai:doaj.org-article:54ec88cc489e422c8098fe2eb7739a0d2021-11-18T07:40:56ZMorbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.1932-620310.1371/journal.pone.0066711https://doaj.org/article/54ec88cc489e422c8098fe2eb7739a0d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23818961/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Hyperthyroidism has been linked with different morbidities, like atrial fibrillation, stroke and diabetes mellitus. However, our knowledge regarding the extent and temporal relation between hyperthyroidism and other diseases is fragmented. Here, we aimed at evaluating various morbidities before and after the diagnosis of hyperthyroidism.<h4>Methods</h4>Observational cohort study. From nationwide Danish health registers 2631 hyperthyroid singletons and 375 twin pairs discordant for hyperthyroidism were identified and followed for an average of 6 years (range 0-13). Data on the occurrence of cardiovascular diseases, lung diseases, diabetes mellitus, rheumatic diseases and malignant diseases was obtained by person-to-person record linkage with the National Danish Patient Register and/or the Danish National Prescription Registry (lung diseases and diabetes mellitus). Logistic and Cox regression models were used to assess the risk of morbidity before and after the diagnosis of hyperthyroidism, respectively. All Cox regression analyses were adjusted for the degree of co-morbidity preceding the diagnosis of hyperthyroidism, using the Charlson score.<h4>Results</h4>Hyperthyroid individuals had a significantly higher risk of being diagnosed with cardiovascular diseases (odds ratio (OR) 1.65; 95% confidence interval (CI): 1.45-1.87), lung diseases (OR 1.53; 95% CI: 1.29-1.60), and diabetes mellitus (OR 1.43, 95% CI: 1.20-1.72), but not with malignant diseases (OR 1.16, 95% CI: 0.99-1.36) prior to the diagnosis of hyperthyroidism. After the diagnosis of hyperthyroidism, subjects had a significantly higher risk of being diagnosed with cardiovascular diseases (hazard ratio (HR) 1.34; 95% CI: 1.15-1.56), lung diseases (HR 1.28; 95% CI: 1.10-1.49), and diabetes mellitus (HR 1.46; 95% CI: 1.16-1.84), but not with rheumatic diseases (HR 1.39, 95% CI: 0.92-2.09) or malignant diseases (HR 1.18, 95% CI 0.97-1.42).<h4>Conclusions</h4>We demonstrate a significantly increased burden of morbidity, both before and after the diagnosis of hyperthyroidism.Frans BrandtMarianne ThvilumDorthe AlmindKaare ChristensenAnders GreenLaszlo HegedüsThomas Heiberg BrixPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66711 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Frans Brandt Marianne Thvilum Dorthe Almind Kaare Christensen Anders Green Laszlo Hegedüs Thomas Heiberg Brix Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.
description	<h4>Background</h4>Hyperthyroidism has been linked with different morbidities, like atrial fibrillation, stroke and diabetes mellitus. However, our knowledge regarding the extent and temporal relation between hyperthyroidism and other diseases is fragmented. Here, we aimed at evaluating various morbidities before and after the diagnosis of hyperthyroidism.<h4>Methods</h4>Observational cohort study. From nationwide Danish health registers 2631 hyperthyroid singletons and 375 twin pairs discordant for hyperthyroidism were identified and followed for an average of 6 years (range 0-13). Data on the occurrence of cardiovascular diseases, lung diseases, diabetes mellitus, rheumatic diseases and malignant diseases was obtained by person-to-person record linkage with the National Danish Patient Register and/or the Danish National Prescription Registry (lung diseases and diabetes mellitus). Logistic and Cox regression models were used to assess the risk of morbidity before and after the diagnosis of hyperthyroidism, respectively. All Cox regression analyses were adjusted for the degree of co-morbidity preceding the diagnosis of hyperthyroidism, using the Charlson score.<h4>Results</h4>Hyperthyroid individuals had a significantly higher risk of being diagnosed with cardiovascular diseases (odds ratio (OR) 1.65; 95% confidence interval (CI): 1.45-1.87), lung diseases (OR 1.53; 95% CI: 1.29-1.60), and diabetes mellitus (OR 1.43, 95% CI: 1.20-1.72), but not with malignant diseases (OR 1.16, 95% CI: 0.99-1.36) prior to the diagnosis of hyperthyroidism. After the diagnosis of hyperthyroidism, subjects had a significantly higher risk of being diagnosed with cardiovascular diseases (hazard ratio (HR) 1.34; 95% CI: 1.15-1.56), lung diseases (HR 1.28; 95% CI: 1.10-1.49), and diabetes mellitus (HR 1.46; 95% CI: 1.16-1.84), but not with rheumatic diseases (HR 1.39, 95% CI: 0.92-2.09) or malignant diseases (HR 1.18, 95% CI 0.97-1.42).<h4>Conclusions</h4>We demonstrate a significantly increased burden of morbidity, both before and after the diagnosis of hyperthyroidism.
format	article
author	Frans Brandt Marianne Thvilum Dorthe Almind Kaare Christensen Anders Green Laszlo Hegedüs Thomas Heiberg Brix
author_facet	Frans Brandt Marianne Thvilum Dorthe Almind Kaare Christensen Anders Green Laszlo Hegedüs Thomas Heiberg Brix
author_sort	Frans Brandt
title	Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.
title_short	Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.
title_full	Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.
title_fullStr	Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.
title_full_unstemmed	Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.
title_sort	morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/54ec88cc489e422c8098fe2eb7739a0d
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Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study.

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