A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.

A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.

Calcium nephrolithiasis is one of the most common causes of renal stones. While the prevalence of this disease has increased steadily over the last 3 decades, its pathogenesis is still unclear. Previous studies have indicated that a genetic polymorphism (rs17251221) in the calcium-sensing receptor g...

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Autores principales: Yii-Her Chou, Peng Yeong Woon, Wei-Chiao Chen, Yu-Wen Hsu, Jer-Ming Chang, Daw-Yang Hwang, Yi-Ching Chiu, Ho-Chang Kuo, Wei-Pin Chang, Ming-Feng Hou, Mu-En Liu, Jan-Gowth Chang, Wei-Chiao Chang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Science
Q
Acceso en línea:https://doaj.org/article/54ed78c6015f4470b17bb43f1f5da173
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spelling oai:doaj.org-article:54ed78c6015f4470b17bb43f1f5da1732021-11-04T06:07:58ZA genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.1932-620310.1371/journal.pone.0025227https://doaj.org/article/54ed78c6015f4470b17bb43f1f5da1732011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966463/?tool=EBIhttps://doaj.org/toc/1932-6203Calcium nephrolithiasis is one of the most common causes of renal stones. While the prevalence of this disease has increased steadily over the last 3 decades, its pathogenesis is still unclear. Previous studies have indicated that a genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with the total serum calcium levels. In this study, we collected DNA samples from 480 Taiwanese subjects (189 calcium nephrolithiasis patients and 291 controls) for genotyping the CASR gene. Our results indicated no significant association between the CASR polymorphism (rs17251221) and the susceptibility of calcium nephrolithiasis. However, we found a significant association between rs17251221 and stone multiplicity. The risk of stone multiplicity was higher in patients with the GG+GA genotype than in those with the AA genotype (chi-square test: P = 0.008; odds ratio  =  4.79; 95% confidence interval, 1.44-15.92; Yates' correction for chi-square test: P = 0.013). In conclusion, our results provide evidence supporting the genetic effects of CASR on the pathogenesis of calcium nephrolithiasis.Yii-Her ChouPeng Yeong WoonWei-Chiao ChenYu-Wen HsuJer-Ming ChangDaw-Yang HwangYi-Ching ChiuHo-Chang KuoWei-Pin ChangMing-Feng HouMu-En LiuJan-Gowth ChangWei-Chiao ChangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e25227 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yii-Her Chou
Peng Yeong Woon
Wei-Chiao Chen
Yu-Wen Hsu
Jer-Ming Chang
Daw-Yang Hwang
Yi-Ching Chiu
Ho-Chang Kuo
Wei-Pin Chang
Ming-Feng Hou
Mu-En Liu
Jan-Gowth Chang
Wei-Chiao Chang
A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.
description Calcium nephrolithiasis is one of the most common causes of renal stones. While the prevalence of this disease has increased steadily over the last 3 decades, its pathogenesis is still unclear. Previous studies have indicated that a genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with the total serum calcium levels. In this study, we collected DNA samples from 480 Taiwanese subjects (189 calcium nephrolithiasis patients and 291 controls) for genotyping the CASR gene. Our results indicated no significant association between the CASR polymorphism (rs17251221) and the susceptibility of calcium nephrolithiasis. However, we found a significant association between rs17251221 and stone multiplicity. The risk of stone multiplicity was higher in patients with the GG+GA genotype than in those with the AA genotype (chi-square test: P = 0.008; odds ratio  =  4.79; 95% confidence interval, 1.44-15.92; Yates' correction for chi-square test: P = 0.013). In conclusion, our results provide evidence supporting the genetic effects of CASR on the pathogenesis of calcium nephrolithiasis.
format article
author Yii-Her Chou
Peng Yeong Woon
Wei-Chiao Chen
Yu-Wen Hsu
Jer-Ming Chang
Daw-Yang Hwang
Yi-Ching Chiu
Ho-Chang Kuo
Wei-Pin Chang
Ming-Feng Hou
Mu-En Liu
Jan-Gowth Chang
Wei-Chiao Chang
author_facet Yii-Her Chou
Peng Yeong Woon
Wei-Chiao Chen
Yu-Wen Hsu
Jer-Ming Chang
Daw-Yang Hwang
Yi-Ching Chiu
Ho-Chang Kuo
Wei-Pin Chang
Ming-Feng Hou
Mu-En Liu
Jan-Gowth Chang
Wei-Chiao Chang
author_sort Yii-Her Chou
title A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.
title_short A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.
title_full A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.
title_fullStr A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.
title_full_unstemmed A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.
title_sort genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (casr) is associated with stone multiplicity in calcium nephrolithiasis.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/54ed78c6015f4470b17bb43f1f5da173
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