Genetic markers of insulin resistance in gestational diabetes

Aim. To search for genetic markers of insulin resistance and impaired insulin secretion in pregnant women with gestational diabetes mellitus (GDM). Materials and methods. A total of 100 healthy pregnant women and 185 patients with GDM were available for examination. 80 patients developedGDM during...

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Autores principales:	Tatiana Vasil'evna Sebko, Yulia Eduardovna Dobrokhotova, Tatiana Alekseevna Ivanova, Valery Vyacheslavovich Nosikov, Tatiana Alekseevna Osipova, Victor Andreevich Potapov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	gestational diabetes mellitus genetic markers insulin resistance obesity Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/54edd9215bed43689089f31bc64aa565
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spelling	oai:doaj.org-article:54edd9215bed43689089f31bc64aa5652021-11-14T09:00:14ZGenetic markers of insulin resistance in gestational diabetes2072-03512072-037810.14341/2072-0351-5702https://doaj.org/article/54edd9215bed43689089f31bc64aa5652009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5702https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To search for genetic markers of insulin resistance and impaired insulin secretion in pregnant women with gestational diabetes mellitus (GDM). Materials and methods. A total of 100 healthy pregnant women and 185 patients with GDM were available for examination. 80 patients developedGDM during current pregnancy, in 105 it was diagnosed 4-19 years ago. 25 of the 105 GDM patients had a history of type 2 DM. The following parameterswere measured: beta-cell secretory activity (proinsulin, ITI, C-peptide), total cholesterol (CH), HDL and LDL CH, triglycerides, HbA1c,fasting glycemia. Molecular-genetic DNA testing using PCR included studies of KCNJ 11, TCF7L2, PPARG2, ADIPOQ, ADIPOR1, ADIPOR2gene polymorphism. These genes were chosen based on the published data associating them with disturbed insulin secretion and sensitivity in DM2patient. Results. Pregnant women with GDM and obesity showed elevated IRI and leptin levels compared with controls. This rise was accompanied bymarked insulin resistance in 75% of these patients. In 50% of the healthy women proinsulin and insulin secretion decreased. Obesity in pregnantpatients was associated with significant elevation of proinsulin, IRI, and C-peptyide levels and GDM with Lys/Lys genotype of polymorphous markerGlu23k of KCNJ11 gene, pro and ala allele of polymorphous marker A219T of ADIPOR2 gene. These associations suggest specific genetic featuresof GDM related to impaired insulin secretion and sensitivity. Conclusion. Studies of common genetic nature of GDM and DM2 permit to identify risk groups at the preclinical stage, plan prevention and treatmentof these disorders.Tatiana Vasil'evna SebkoYulia Eduardovna DobrokhotovaTatiana Alekseevna IvanovaValery Vyacheslavovich NosikovTatiana Alekseevna OsipovaVictor Andreevich PotapovEndocrinology Research Centrearticlegestational diabetes mellitusgenetic markersinsulin resistanceobesityNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 38-41 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	gestational diabetes mellitus genetic markers insulin resistance obesity Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	gestational diabetes mellitus genetic markers insulin resistance obesity Nutritional diseases. Deficiency diseases RC620-627 Tatiana Vasil'evna Sebko Yulia Eduardovna Dobrokhotova Tatiana Alekseevna Ivanova Valery Vyacheslavovich Nosikov Tatiana Alekseevna Osipova Victor Andreevich Potapov Genetic markers of insulin resistance in gestational diabetes
description	Aim. To search for genetic markers of insulin resistance and impaired insulin secretion in pregnant women with gestational diabetes mellitus (GDM). Materials and methods. A total of 100 healthy pregnant women and 185 patients with GDM were available for examination. 80 patients developedGDM during current pregnancy, in 105 it was diagnosed 4-19 years ago. 25 of the 105 GDM patients had a history of type 2 DM. The following parameterswere measured: beta-cell secretory activity (proinsulin, ITI, C-peptide), total cholesterol (CH), HDL and LDL CH, triglycerides, HbA1c,fasting glycemia. Molecular-genetic DNA testing using PCR included studies of KCNJ 11, TCF7L2, PPARG2, ADIPOQ, ADIPOR1, ADIPOR2gene polymorphism. These genes were chosen based on the published data associating them with disturbed insulin secretion and sensitivity in DM2patient. Results. Pregnant women with GDM and obesity showed elevated IRI and leptin levels compared with controls. This rise was accompanied bymarked insulin resistance in 75% of these patients. In 50% of the healthy women proinsulin and insulin secretion decreased. Obesity in pregnantpatients was associated with significant elevation of proinsulin, IRI, and C-peptyide levels and GDM with Lys/Lys genotype of polymorphous markerGlu23k of KCNJ11 gene, pro and ala allele of polymorphous marker A219T of ADIPOR2 gene. These associations suggest specific genetic featuresof GDM related to impaired insulin secretion and sensitivity. Conclusion. Studies of common genetic nature of GDM and DM2 permit to identify risk groups at the preclinical stage, plan prevention and treatmentof these disorders.
format	article
author	Tatiana Vasil'evna Sebko Yulia Eduardovna Dobrokhotova Tatiana Alekseevna Ivanova Valery Vyacheslavovich Nosikov Tatiana Alekseevna Osipova Victor Andreevich Potapov
author_facet	Tatiana Vasil'evna Sebko Yulia Eduardovna Dobrokhotova Tatiana Alekseevna Ivanova Valery Vyacheslavovich Nosikov Tatiana Alekseevna Osipova Victor Andreevich Potapov
author_sort	Tatiana Vasil'evna Sebko
title	Genetic markers of insulin resistance in gestational diabetes
title_short	Genetic markers of insulin resistance in gestational diabetes
title_full	Genetic markers of insulin resistance in gestational diabetes
title_fullStr	Genetic markers of insulin resistance in gestational diabetes
title_full_unstemmed	Genetic markers of insulin resistance in gestational diabetes
title_sort	genetic markers of insulin resistance in gestational diabetes
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/54edd9215bed43689089f31bc64aa565
work_keys_str_mv	AT tatianavasilevnasebko geneticmarkersofinsulinresistanceingestationaldiabetes AT yuliaeduardovnadobrokhotova geneticmarkersofinsulinresistanceingestationaldiabetes AT tatianaalekseevnaivanova geneticmarkersofinsulinresistanceingestationaldiabetes AT valeryvyacheslavovichnosikov geneticmarkersofinsulinresistanceingestationaldiabetes AT tatianaalekseevnaosipova geneticmarkersofinsulinresistanceingestationaldiabetes AT victorandreevichpotapov geneticmarkersofinsulinresistanceingestationaldiabetes
_version_	1718429648889577472

Genetic markers of insulin resistance in gestational diabetes

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