Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia

Objective Hyperbilirubinemia is one of the most common clinical symptoms in newborns. To improve patient outcomes, evidence-based and implementable guidelines are required. However, clinical guidelines may vary in quality, criteria and recommendations among regions and countries. In this study, we a...

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Autores principales:	Dezhi Mu, Meng Zhang, Jun Tang, Yi Qu, Tao Xiong, Zhong Chen, Yang He, Wenxing Li, Youping Li
Formato:	article
Lenguaje:	EN
Publicado:	BMJ Publishing Group 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/54ee1f2f13054f4cbcf61ae098aa6bed
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spelling	oai:doaj.org-article:54ee1f2f13054f4cbcf61ae098aa6bed2021-11-18T11:00:08ZSystematic review of global clinical practice guidelines for neonatal hyperbilirubinemia10.1136/bmjopen-2020-0401822044-6055https://doaj.org/article/54ee1f2f13054f4cbcf61ae098aa6bed2021-01-01T00:00:00Zhttps://bmjopen.bmj.com/content/11/1/e040182.fullhttps://doaj.org/toc/2044-6055Objective Hyperbilirubinemia is one of the most common clinical symptoms in newborns. To improve patient outcomes, evidence-based and implementable guidelines are required. However, clinical guidelines may vary in quality, criteria and recommendations among regions and countries. In this study, we aimed to systematically assess the quality of guidelines using the Appraisal of Guidelines for Research & Evaluation (AGREE)-II instrument and summarise the specific recommendations for neonatal hyperbilirubinemia in order to provide suggestions for future guideline development.Design Systematic review.Interventions We searched the PubMed, Embase, Medline and guideline databases for relevant articles on 10 April 2020. The studies were screened by two independent reviewers according to our inclusion criteria. Two reviewers independently extracted the descriptive data. Four appraisers assessed the guidelines using the AGREE-II instrument.Results Our systematic review appraised 12 clinical practice guidelines for the diagnosis and management of neonatal hyperbilirubinemia. The 12 guidelines achieved an average score of 36%–89%. The guidelines received the highest scores for clarity of presentation and lowest scores for rigour of development. Most recommendations for diagnosis were relatively consistent, but recommendations regarding risk factors, the initiating threshold of treatment and pharmacotherapy varied.Conclusions Our study revealed that current guidelines vary in the quality of the developing process and are inconsistent with regards to recommendations. Future guidelines should afford more attention to the quality of methodologies in guideline development, and more qualified evidence is needed to standardise the initiating threshold of treatment for neonatal hyperbilirubinemia.Dezhi MuMeng ZhangJun TangYi QuTao XiongZhong ChenYang HeWenxing LiYouping LiBMJ Publishing GrouparticleMedicineRENBMJ Open, Vol 11, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Dezhi Mu Meng Zhang Jun Tang Yi Qu Tao Xiong Zhong Chen Yang He Wenxing Li Youping Li Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia
description	Objective Hyperbilirubinemia is one of the most common clinical symptoms in newborns. To improve patient outcomes, evidence-based and implementable guidelines are required. However, clinical guidelines may vary in quality, criteria and recommendations among regions and countries. In this study, we aimed to systematically assess the quality of guidelines using the Appraisal of Guidelines for Research & Evaluation (AGREE)-II instrument and summarise the specific recommendations for neonatal hyperbilirubinemia in order to provide suggestions for future guideline development.Design Systematic review.Interventions We searched the PubMed, Embase, Medline and guideline databases for relevant articles on 10 April 2020. The studies were screened by two independent reviewers according to our inclusion criteria. Two reviewers independently extracted the descriptive data. Four appraisers assessed the guidelines using the AGREE-II instrument.Results Our systematic review appraised 12 clinical practice guidelines for the diagnosis and management of neonatal hyperbilirubinemia. The 12 guidelines achieved an average score of 36%–89%. The guidelines received the highest scores for clarity of presentation and lowest scores for rigour of development. Most recommendations for diagnosis were relatively consistent, but recommendations regarding risk factors, the initiating threshold of treatment and pharmacotherapy varied.Conclusions Our study revealed that current guidelines vary in the quality of the developing process and are inconsistent with regards to recommendations. Future guidelines should afford more attention to the quality of methodologies in guideline development, and more qualified evidence is needed to standardise the initiating threshold of treatment for neonatal hyperbilirubinemia.
format	article
author	Dezhi Mu Meng Zhang Jun Tang Yi Qu Tao Xiong Zhong Chen Yang He Wenxing Li Youping Li
author_facet	Dezhi Mu Meng Zhang Jun Tang Yi Qu Tao Xiong Zhong Chen Yang He Wenxing Li Youping Li
author_sort	Dezhi Mu
title	Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia
title_short	Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia
title_full	Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia
title_fullStr	Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia
title_full_unstemmed	Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia
title_sort	systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia
publisher	BMJ Publishing Group
publishDate	2021
url	https://doaj.org/article/54ee1f2f13054f4cbcf61ae098aa6bed
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Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia

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