Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

Summary: The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) were...

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Autores principales:	Naofumi Yoshida, Tomoya Yamashita, Tatsunori Osone, Tetsuya Hosooka, Masakazu Shinohara, Seiichi Kitahama, Kengo Sasaki, Daisuke Sasaki, Takeshi Yoneshiro, Tomohiro Suzuki, Takuo Emoto, Yoshihiro Saito, Genki Ozawa, Yushi Hirota, Yasuyuki Kitaura, Yoshiharu Shimomura, Yuko Okamatsu-Ogura, Masayuki Saito, Akihiko Kondo, Shingo Kajimura, Takeshi Inagaki, Wataru Ogawa, Takuji Yamada, Ken-ichi Hirata
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Computer systems organization Energy engineering Energy systems Science Q
Acceso en línea:	https://doaj.org/article/54ef087fe8ce4247835125bd4322e949
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spelling	oai:doaj.org-article:54ef087fe8ce4247835125bd4322e9492021-11-20T05:10:12ZBacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity2589-004210.1016/j.isci.2021.103342https://doaj.org/article/54ef087fe8ce4247835125bd4322e9492021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013110https://doaj.org/toc/2589-0042Summary: The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) were significantly correlated with the body weight in humans and mice and that BCAA catabolic defects in BAT were associated with obesity in diet-induced obesity (DIO) mice. Pharmacological systemic enhancement of BCAA catabolic activity reduced plasma BCAA and BCKA levels and protected against obesity; these effects were reduced in BATectomized mice. DIO mice gavaged with Bacteroides dorei and Bacteroides vulgatus exhibited improved BAT BCAA catabolism and attenuated body weight gain, which were not observed in BATectomized DIO mice. Our data have highlighted a possible link between the gut microbiota and BAT BCAA catabolism and suggest that Bacteroides probiotics could be used for treating obesity.Naofumi YoshidaTomoya YamashitaTatsunori OsoneTetsuya HosookaMasakazu ShinoharaSeiichi KitahamaKengo SasakiDaisuke SasakiTakeshi YoneshiroTomohiro SuzukiTakuo EmotoYoshihiro SaitoGenki OzawaYushi HirotaYasuyuki KitauraYoshiharu ShimomuraYuko Okamatsu-OguraMasayuki SaitoAkihiko KondoShingo KajimuraTakeshi InagakiWataru OgawaTakuji YamadaKen-ichi HirataElsevierarticleComputer systems organizationEnergy engineeringEnergy systemsScienceQENiScience, Vol 24, Iss 11, Pp 103342- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer systems organization Energy engineering Energy systems Science Q
spellingShingle	Computer systems organization Energy engineering Energy systems Science Q Naofumi Yoshida Tomoya Yamashita Tatsunori Osone Tetsuya Hosooka Masakazu Shinohara Seiichi Kitahama Kengo Sasaki Daisuke Sasaki Takeshi Yoneshiro Tomohiro Suzuki Takuo Emoto Yoshihiro Saito Genki Ozawa Yushi Hirota Yasuyuki Kitaura Yoshiharu Shimomura Yuko Okamatsu-Ogura Masayuki Saito Akihiko Kondo Shingo Kajimura Takeshi Inagaki Wataru Ogawa Takuji Yamada Ken-ichi Hirata Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
description	Summary: The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) were significantly correlated with the body weight in humans and mice and that BCAA catabolic defects in BAT were associated with obesity in diet-induced obesity (DIO) mice. Pharmacological systemic enhancement of BCAA catabolic activity reduced plasma BCAA and BCKA levels and protected against obesity; these effects were reduced in BATectomized mice. DIO mice gavaged with Bacteroides dorei and Bacteroides vulgatus exhibited improved BAT BCAA catabolism and attenuated body weight gain, which were not observed in BATectomized DIO mice. Our data have highlighted a possible link between the gut microbiota and BAT BCAA catabolism and suggest that Bacteroides probiotics could be used for treating obesity.
format	article
author	Naofumi Yoshida Tomoya Yamashita Tatsunori Osone Tetsuya Hosooka Masakazu Shinohara Seiichi Kitahama Kengo Sasaki Daisuke Sasaki Takeshi Yoneshiro Tomohiro Suzuki Takuo Emoto Yoshihiro Saito Genki Ozawa Yushi Hirota Yasuyuki Kitaura Yoshiharu Shimomura Yuko Okamatsu-Ogura Masayuki Saito Akihiko Kondo Shingo Kajimura Takeshi Inagaki Wataru Ogawa Takuji Yamada Ken-ichi Hirata
author_facet	Naofumi Yoshida Tomoya Yamashita Tatsunori Osone Tetsuya Hosooka Masakazu Shinohara Seiichi Kitahama Kengo Sasaki Daisuke Sasaki Takeshi Yoneshiro Tomohiro Suzuki Takuo Emoto Yoshihiro Saito Genki Ozawa Yushi Hirota Yasuyuki Kitaura Yoshiharu Shimomura Yuko Okamatsu-Ogura Masayuki Saito Akihiko Kondo Shingo Kajimura Takeshi Inagaki Wataru Ogawa Takuji Yamada Ken-ichi Hirata
author_sort	Naofumi Yoshida
title	Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
title_short	Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
title_full	Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
title_fullStr	Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
title_full_unstemmed	Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
title_sort	bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/54ef087fe8ce4247835125bd4322e949
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Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

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