Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines

We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011–2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Se...

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Autores principales:	Lucía Fernández-Delgado, Jordi Càmara, Aida González-Díaz, Immaculada Grau, Hisashi Shoji, Fe Tubau, Sara Martí, Mª Ángeles Domínguez, Jordi Carratalà, Jose Yuste, Carmen Ardanuy
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Streptococcus pneumoniae</i> pneumonia serotype antimicrobial resistance pneumococcal conjugate vaccines (PCVs) Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/54ef7f10a8e94279b69a0d834669a3b5
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spelling	oai:doaj.org-article:54ef7f10a8e94279b69a0d834669a3b52021-11-25T18:24:33ZSerotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines10.3390/microorganisms91122452076-2607https://doaj.org/article/54ef7f10a8e94279b69a0d834669a3b52021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2245https://doaj.org/toc/2076-2607We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011–2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Serotypes 16F, 19A and 24F were associated with old people (≥65) and serotypes 4, 7F, 8, 12F and 19F to young adults. Serotypes 12F, 24F and 1 were significantly more frequent in BPP and serotypes 11A, 23A and 19F in non-BPP. Amoxicillin resistance was higher in non-BPP (17% vs. 11%) while penicillin non-susceptibility (37% vs. 24%) and macrolide resistance (29% vs. 14%) were higher in older adults. In the period 2017–2019, the vaccine coverages were: 32% (PCV13), 39% (PCV15), 65% (PCV20) and 69% (PPV23). Differences were found in serotype composition and antimicrobial resistance by age and type of infection. The maintenance of serotype 3 as a leading cause of adult pneumococcal pneumonia and the increase in highly invasive (serotype 8) or antimicrobial-resistant (serotype 11A) serotypes is worrisome. Further studies will be required to analyse the impact of the upcoming broader conjugate vaccines.Lucía Fernández-DelgadoJordi CàmaraAida González-DíazImmaculada GrauHisashi ShojiFe TubauSara MartíMª Ángeles DomínguezJordi CarratalàJose YusteCarmen ArdanuyMDPI AGarticle<i>Streptococcus pneumoniae</i>pneumoniaserotypeantimicrobial resistancepneumococcal conjugate vaccines (PCVs)Biology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2245, p 2245 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Streptococcus pneumoniae</i> pneumonia serotype antimicrobial resistance pneumococcal conjugate vaccines (PCVs) Biology (General) QH301-705.5
spellingShingle	<i>Streptococcus pneumoniae</i> pneumonia serotype antimicrobial resistance pneumococcal conjugate vaccines (PCVs) Biology (General) QH301-705.5 Lucía Fernández-Delgado Jordi Càmara Aida González-Díaz Immaculada Grau Hisashi Shoji Fe Tubau Sara Martí Mª Ángeles Domínguez Jordi Carratalà Jose Yuste Carmen Ardanuy Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines
description	We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011–2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Serotypes 16F, 19A and 24F were associated with old people (≥65) and serotypes 4, 7F, 8, 12F and 19F to young adults. Serotypes 12F, 24F and 1 were significantly more frequent in BPP and serotypes 11A, 23A and 19F in non-BPP. Amoxicillin resistance was higher in non-BPP (17% vs. 11%) while penicillin non-susceptibility (37% vs. 24%) and macrolide resistance (29% vs. 14%) were higher in older adults. In the period 2017–2019, the vaccine coverages were: 32% (PCV13), 39% (PCV15), 65% (PCV20) and 69% (PPV23). Differences were found in serotype composition and antimicrobial resistance by age and type of infection. The maintenance of serotype 3 as a leading cause of adult pneumococcal pneumonia and the increase in highly invasive (serotype 8) or antimicrobial-resistant (serotype 11A) serotypes is worrisome. Further studies will be required to analyse the impact of the upcoming broader conjugate vaccines.
format	article
author	Lucía Fernández-Delgado Jordi Càmara Aida González-Díaz Immaculada Grau Hisashi Shoji Fe Tubau Sara Martí Mª Ángeles Domínguez Jordi Carratalà Jose Yuste Carmen Ardanuy
author_facet	Lucía Fernández-Delgado Jordi Càmara Aida González-Díaz Immaculada Grau Hisashi Shoji Fe Tubau Sara Martí Mª Ángeles Domínguez Jordi Carratalà Jose Yuste Carmen Ardanuy
author_sort	Lucía Fernández-Delgado
title	Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines
title_short	Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines
title_full	Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines
title_fullStr	Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines
title_full_unstemmed	Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines
title_sort	serotypes in adult pneumococcal pneumonia in spain in the era of conjugate vaccines
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/54ef7f10a8e94279b69a0d834669a3b5
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Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines

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