Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer

The era of immunotherapy has seen an insurgence of novel therapies driving oncologic research and the clinical management of the disease. We have previously reported that a combination of chemotherapy (FEC) and oncolytic virotherapy (oHSV-1) can be used to sensitize otherwise non-responsive tumors t...

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Autores principales:	Alyssa Vito, Nader El-Sayes, Omar Salem, Yonghong Wan, Karen L. Mossman
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	triple-negative breast cancer breast cancer immunotherapy B cells myeloid cells tumor microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/54ef9e75b2034b34afefbf21316d3cb5
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spelling	oai:doaj.org-article:54ef9e75b2034b34afefbf21316d3cb52021-11-11T15:36:21ZResponse to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer10.3390/cancers132155902072-6694https://doaj.org/article/54ef9e75b2034b34afefbf21316d3cb52021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5590https://doaj.org/toc/2072-6694The era of immunotherapy has seen an insurgence of novel therapies driving oncologic research and the clinical management of the disease. We have previously reported that a combination of chemotherapy (FEC) and oncolytic virotherapy (oHSV-1) can be used to sensitize otherwise non-responsive tumors to immune checkpoint blockade and that tumor-infiltrating B cells are required for the efficacy of our therapeutic regimen in a murine model of triple-negative breast cancer. In the studies herein, we have performed gene expression profiling using microarray analyses and have investigated the differential gene expression between tumors treated with FEC + oHSV-1 versus untreated tumors. In this work, we uncovered a therapeutically driven switch of the myeloid phenotype and a gene signature driving increased tumor cell killing.Alyssa VitoNader El-SayesOmar SalemYonghong WanKaren L. MossmanMDPI AGarticletriple-negative breast cancerbreast cancerimmunotherapyB cellsmyeloid cellstumor microenvironmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5590, p 5590 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	triple-negative breast cancer breast cancer immunotherapy B cells myeloid cells tumor microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	triple-negative breast cancer breast cancer immunotherapy B cells myeloid cells tumor microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alyssa Vito Nader El-Sayes Omar Salem Yonghong Wan Karen L. Mossman Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer
description	The era of immunotherapy has seen an insurgence of novel therapies driving oncologic research and the clinical management of the disease. We have previously reported that a combination of chemotherapy (FEC) and oncolytic virotherapy (oHSV-1) can be used to sensitize otherwise non-responsive tumors to immune checkpoint blockade and that tumor-infiltrating B cells are required for the efficacy of our therapeutic regimen in a murine model of triple-negative breast cancer. In the studies herein, we have performed gene expression profiling using microarray analyses and have investigated the differential gene expression between tumors treated with FEC + oHSV-1 versus untreated tumors. In this work, we uncovered a therapeutically driven switch of the myeloid phenotype and a gene signature driving increased tumor cell killing.
format	article
author	Alyssa Vito Nader El-Sayes Omar Salem Yonghong Wan Karen L. Mossman
author_facet	Alyssa Vito Nader El-Sayes Omar Salem Yonghong Wan Karen L. Mossman
author_sort	Alyssa Vito
title	Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer
title_short	Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer
title_full	Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer
title_fullStr	Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer
title_full_unstemmed	Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer
title_sort	response to fec chemotherapy and oncolytic hsv-1 is associated with macrophage polarization and increased expression of s100a8/a9 in triple negative breast cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/54ef9e75b2034b34afefbf21316d3cb5
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Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer

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