Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

G3BP1 is RasGAP SH3 domain binding protein 1 that interacts with 48S pre-initiation complex when translation is stalled. Here, Twiss and colleagues show that neuronal G3BP1 can negatively regulate axonal mRNA translation, and inhibit axonal regeneration after injury.

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Autores principales:	Pabitra K. Sahoo, Seung Joon Lee, Poonam B. Jaiswal, Stefanie Alber, Amar N. Kar, Sharmina Miller-Randolph, Elizabeth E. Taylor, Terika Smith, Bhagat Singh, Tammy Szu-Yu Ho, Anatoly Urisman, Shreya Chand, Edsel A. Pena, Alma L. Burlingame, Clifford J. Woolf, Mike Fainzilber, Arthur W. English, Jeffery L. Twiss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54f17aef7ce54eff8c30573b11316ce9
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spelling	oai:doaj.org-article:54f17aef7ce54eff8c30573b11316ce92021-12-02T17:32:18ZAxonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration10.1038/s41467-018-05647-x2041-1723https://doaj.org/article/54f17aef7ce54eff8c30573b11316ce92018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05647-xhttps://doaj.org/toc/2041-1723G3BP1 is RasGAP SH3 domain binding protein 1 that interacts with 48S pre-initiation complex when translation is stalled. Here, Twiss and colleagues show that neuronal G3BP1 can negatively regulate axonal mRNA translation, and inhibit axonal regeneration after injury.Pabitra K. SahooSeung Joon LeePoonam B. JaiswalStefanie AlberAmar N. KarSharmina Miller-RandolphElizabeth E. TaylorTerika SmithBhagat SinghTammy Szu-Yu HoAnatoly UrismanShreya ChandEdsel A. PenaAlma L. BurlingameClifford J. WoolfMike FainzilberArthur W. EnglishJeffery L. TwissNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pabitra K. Sahoo Seung Joon Lee Poonam B. Jaiswal Stefanie Alber Amar N. Kar Sharmina Miller-Randolph Elizabeth E. Taylor Terika Smith Bhagat Singh Tammy Szu-Yu Ho Anatoly Urisman Shreya Chand Edsel A. Pena Alma L. Burlingame Clifford J. Woolf Mike Fainzilber Arthur W. English Jeffery L. Twiss Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
description	G3BP1 is RasGAP SH3 domain binding protein 1 that interacts with 48S pre-initiation complex when translation is stalled. Here, Twiss and colleagues show that neuronal G3BP1 can negatively regulate axonal mRNA translation, and inhibit axonal regeneration after injury.
format	article
author	Pabitra K. Sahoo Seung Joon Lee Poonam B. Jaiswal Stefanie Alber Amar N. Kar Sharmina Miller-Randolph Elizabeth E. Taylor Terika Smith Bhagat Singh Tammy Szu-Yu Ho Anatoly Urisman Shreya Chand Edsel A. Pena Alma L. Burlingame Clifford J. Woolf Mike Fainzilber Arthur W. English Jeffery L. Twiss
author_facet	Pabitra K. Sahoo Seung Joon Lee Poonam B. Jaiswal Stefanie Alber Amar N. Kar Sharmina Miller-Randolph Elizabeth E. Taylor Terika Smith Bhagat Singh Tammy Szu-Yu Ho Anatoly Urisman Shreya Chand Edsel A. Pena Alma L. Burlingame Clifford J. Woolf Mike Fainzilber Arthur W. English Jeffery L. Twiss
author_sort	Pabitra K. Sahoo
title	Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
title_short	Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
title_full	Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
title_fullStr	Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
title_full_unstemmed	Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
title_sort	axonal g3bp1 stress granule protein limits axonal mrna translation and nerve regeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/54f17aef7ce54eff8c30573b11316ce9
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Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

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