Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)

Abstract Two new cyclopentapeptides, xylapeptide A (1) with an uncommon L-pipecolinic acid moiety, and xylapeptide B (2) having a common L-proline residue were identified from an associated fungus Xylaria sp. isolated from the Chinese medicinal plant Sophora tonkinensis. Their planar structures were...

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Autores principales:	Wei-Feng Xu, Xue-Mei Hou, Fei-Hua Yao, Na Zheng, Jun Li, Chang-Yun Wang, Rui-Yun Yang, Chang-Lun Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54f1a2416b1b442fa0a247efb28f8cde
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spelling	oai:doaj.org-article:54f1a2416b1b442fa0a247efb28f8cde2021-12-02T15:04:59ZXylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)10.1038/s41598-017-07331-42045-2322https://doaj.org/article/54f1a2416b1b442fa0a247efb28f8cde2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07331-4https://doaj.org/toc/2045-2322Abstract Two new cyclopentapeptides, xylapeptide A (1) with an uncommon L-pipecolinic acid moiety, and xylapeptide B (2) having a common L-proline residue were identified from an associated fungus Xylaria sp. isolated from the Chinese medicinal plant Sophora tonkinensis. Their planar structures were elucidated by a comprehensive analysis of NMR and MS spectroscopic spectra. The absolute configurations were determined by Marfey’s method and single-crystal X-ray diffraction (Cu Kα) analysis. Xylapeptide A (1) is the first example of cyclopentapeptide with L-Pip of terrestrial origin and showed strong antibacterial activity against Bacillus subtilis and B. cereus with MIC value of 12.5 μg/mL.Wei-Feng XuXue-Mei HouFei-Hua YaoNa ZhengJun LiChang-Yun WangRui-Yun YangChang-Lun ShaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei-Feng Xu Xue-Mei Hou Fei-Hua Yao Na Zheng Jun Li Chang-Yun Wang Rui-Yun Yang Chang-Lun Shao Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
description	Abstract Two new cyclopentapeptides, xylapeptide A (1) with an uncommon L-pipecolinic acid moiety, and xylapeptide B (2) having a common L-proline residue were identified from an associated fungus Xylaria sp. isolated from the Chinese medicinal plant Sophora tonkinensis. Their planar structures were elucidated by a comprehensive analysis of NMR and MS spectroscopic spectra. The absolute configurations were determined by Marfey’s method and single-crystal X-ray diffraction (Cu Kα) analysis. Xylapeptide A (1) is the first example of cyclopentapeptide with L-Pip of terrestrial origin and showed strong antibacterial activity against Bacillus subtilis and B. cereus with MIC value of 12.5 μg/mL.
format	article
author	Wei-Feng Xu Xue-Mei Hou Fei-Hua Yao Na Zheng Jun Li Chang-Yun Wang Rui-Yun Yang Chang-Lun Shao
author_facet	Wei-Feng Xu Xue-Mei Hou Fei-Hua Yao Na Zheng Jun Li Chang-Yun Wang Rui-Yun Yang Chang-Lun Shao
author_sort	Wei-Feng Xu
title	Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
title_short	Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
title_full	Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
title_fullStr	Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
title_full_unstemmed	Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
title_sort	xylapeptide a, an antibacterial cyclopentapeptide with an uncommon l-pipecolinic acid moiety from the associated fungus xylaria sp. (gdg-102)
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/54f1a2416b1b442fa0a247efb28f8cde
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Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)

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