Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma

Marius Heersink,1 Jesse A Dovich21University of Alabama School of Medicine, Birmingham, AL, USA; 2Pacific Eye Institute, Upland, CA, USAPurpose: Evaluate outcomes of trabecular meshwork (TM) bypass (iStent® GTS100) with cataract extraction (CE) and TM-bypass + ab interno ca...

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Autores principales:	Heersink M, Dovich JA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	360-degree trabeculotomy canaloplasty MIGS glaucoma VISCO360 viscodilation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/54f289498a214bb092cd6b6c3483e73e
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spelling	oai:doaj.org-article:54f289498a214bb092cd6b6c3483e73e2021-12-02T08:10:53ZAb interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma1177-5483https://doaj.org/article/54f289498a214bb092cd6b6c3483e73e2019-08-01T00:00:00Zhttps://www.dovepress.com/ab-interno-canaloplasty-combined-with-trabecular-bypass-stenting-in-ey-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Marius Heersink,1 Jesse A Dovich21University of Alabama School of Medicine, Birmingham, AL, USA; 2Pacific Eye Institute, Upland, CA, USAPurpose: Evaluate outcomes of trabecular meshwork (TM) bypass (iStent® GTS100) with cataract extraction (CE) and TM-bypass + ab interno canaloplasty (CP) (VISCO360®) with CE in patients with primary open-angle glaucoma (POAG).Setting: Private surgical center for a comprehensive ophthalmology practiceDesign: Retrospective analysis of 186 eyes from 130 consecutive patients with 6 months follow-up.Methods: Eligible eyes had POAG, indicated for CE, and had received CE + TM-bypass or CE + TM-bypass + CP. Exclusions: glaucomas not POAG, SLT within 6 months, or previous ALT. IOP, visual acuity, and medication use assessed at baseline, months 1, 3, and 6. Endpoints were mean reduction in IOP from baseline at 6 months, proportion with IOP reduction at 6 months of ≥20% and IOP <18 mmHg on same or fewer medications, mean medication reduction, and proportion medication independent.Results: Eighty-six eyes comprised the CE + TM-bypass + CP group; 100 eyes in the CE + TM-bypass group. At 6 months: mean IOP reduction was 2.9±3.6 mmHg for CE + TM-bypass + CP and 1.7±3.1 mmHg for CE + TM-bypass group (P<0.05); the proportion with IOP reduction of ≥20% and an IOP <18 mmHg on the same or fewer medications was 46% for CE + TM-bypass + CP and 35% for CE + TM-bypass; for both CE + TM-bypass + CP and CE + TM-bypass, mean number of medications was decreased (0.9 and 0.7, P<0.0001) with 56% and 48% off all medication. The most common AE were inflammation (6%) for CE + TM-bypass + CP group and VA loss (8%) for CE + TM-bypass.Conclusion: At six months, a greater proportion of CE + TM-bypass + CP patients achieved IOP reduction of ≥20% and an IOP <18 mmHg on the same or fewer medications than for TM-bypass + CE.Keywords: 360-degree viscodilation, canaloplasty, MIGS, glaucoma, VISCO360,® viscodilationHeersink MDovich JADove Medical Pressarticle360-degree trabeculotomycanaloplastyMIGSglaucomaVISCO360viscodilationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1533-1542 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	360-degree trabeculotomy canaloplasty MIGS glaucoma VISCO360 viscodilation Ophthalmology RE1-994
spellingShingle	360-degree trabeculotomy canaloplasty MIGS glaucoma VISCO360 viscodilation Ophthalmology RE1-994 Heersink M Dovich JA Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma
description	Marius Heersink,1 Jesse A Dovich21University of Alabama School of Medicine, Birmingham, AL, USA; 2Pacific Eye Institute, Upland, CA, USAPurpose: Evaluate outcomes of trabecular meshwork (TM) bypass (iStent® GTS100) with cataract extraction (CE) and TM-bypass + ab interno canaloplasty (CP) (VISCO360®) with CE in patients with primary open-angle glaucoma (POAG).Setting: Private surgical center for a comprehensive ophthalmology practiceDesign: Retrospective analysis of 186 eyes from 130 consecutive patients with 6 months follow-up.Methods: Eligible eyes had POAG, indicated for CE, and had received CE + TM-bypass or CE + TM-bypass + CP. Exclusions: glaucomas not POAG, SLT within 6 months, or previous ALT. IOP, visual acuity, and medication use assessed at baseline, months 1, 3, and 6. Endpoints were mean reduction in IOP from baseline at 6 months, proportion with IOP reduction at 6 months of ≥20% and IOP <18 mmHg on same or fewer medications, mean medication reduction, and proportion medication independent.Results: Eighty-six eyes comprised the CE + TM-bypass + CP group; 100 eyes in the CE + TM-bypass group. At 6 months: mean IOP reduction was 2.9±3.6 mmHg for CE + TM-bypass + CP and 1.7±3.1 mmHg for CE + TM-bypass group (P<0.05); the proportion with IOP reduction of ≥20% and an IOP <18 mmHg on the same or fewer medications was 46% for CE + TM-bypass + CP and 35% for CE + TM-bypass; for both CE + TM-bypass + CP and CE + TM-bypass, mean number of medications was decreased (0.9 and 0.7, P<0.0001) with 56% and 48% off all medication. The most common AE were inflammation (6%) for CE + TM-bypass + CP group and VA loss (8%) for CE + TM-bypass.Conclusion: At six months, a greater proportion of CE + TM-bypass + CP patients achieved IOP reduction of ≥20% and an IOP <18 mmHg on the same or fewer medications than for TM-bypass + CE.Keywords: 360-degree viscodilation, canaloplasty, MIGS, glaucoma, VISCO360,® viscodilation
format	article
author	Heersink M Dovich JA
author_facet	Heersink M Dovich JA
author_sort	Heersink M
title	Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma
title_short	Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma
title_full	Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma
title_fullStr	Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma
title_full_unstemmed	Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma
title_sort	ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/54f289498a214bb092cd6b6c3483e73e
work_keys_str_mv	AT heersinkm abinternocanaloplastycombinedwithtrabecularbypassstentingineyeswithprimaryopenangleglaucoma AT dovichja abinternocanaloplastycombinedwithtrabecularbypassstentingineyeswithprimaryopenangleglaucoma
_version_	1718398599667122176

Ab interno canaloplasty combined with trabecular bypass stenting in eyes with primary open-angle glaucoma

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