Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa

Vijay Bhooshan Kumar,1 Michal Natan,2 Gila Jacobi,2 Ze’ev Porat,3,4 Ehud Banin,2 Aharon Gedanken1,5 1Department of Chemistry, 2Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan Institute for Nanotechnology and Advanced Materials Bar-Ilan University, Ramat Gan, 3Division of Chemi...

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Autores principales:	Kumar VB, Natan M, Jacobi G, Porat Z, Banin E, Gedanken A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	C-dots Ga@C-dots Sonochemistry Gallium Antibacterial Pseudomonas aeruginosa Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/54f6b83f63f44d3d8f5271b31fb9b01d
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spelling	oai:doaj.org-article:54f6b83f63f44d3d8f5271b31fb9b01d2021-12-02T00:45:56ZGa@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa1178-2013https://doaj.org/article/54f6b83f63f44d3d8f5271b31fb9b01d2017-01-01T00:00:00Zhttps://www.dovepress.com/gac-dots-as-an-antibacterial-agent-for-the-eradication-of-pseudomonas--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Vijay Bhooshan Kumar,1 Michal Natan,2 Gila Jacobi,2 Ze’ev Porat,3,4 Ehud Banin,2 Aharon Gedanken1,5 1Department of Chemistry, 2Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan Institute for Nanotechnology and Advanced Materials Bar-Ilan University, Ramat Gan, 3Division of Chemistry, Nuclear Research Center-Negev, 4Institutes of Applied Research, Ben-Gurion University of the Negev, Be’er-Sheva, Israel; 5National Cheng Kung University, Department of Materials Science and Engineering, Tainan, Taiwan Abstract: The opportunistic pathogen Pseudomonas aeruginosa causes infections that are difficult to treat by antibiotic therapy. This research article reports on the synthesis of gallium (Ga) doped in carbon (C)-dots (Ga@C-dots) and their antimicrobial activity against free-living P. aeruginosa bacteria. The synthesis of Ga@C-dots was carried out by sonicating molten Ga (for 2.5 h) in polyethylene glycol-400, which acts as both a medium and carbon source. The resultant Ga@C-dots, having an average diameter of 9±2 nm, showed remarkably enhanced antibacterial activity compared with undoped C-dots. This was reflected by the much lower concentration of Ga doped within Ga@C-dots which was required for full inhibition of the bacterial growth. These results highlight the possibility of using Ga@C-dots as potential antimicrobial agents. Keywords: C-dots, Ga@C-dots, sonochemistry, gallium, antibacterial, Pseudomonas aeruginosaKumar VBNatan MJacobi GPorat ZBanin EGedanken ADove Medical PressarticleC-dotsGa@C-dotsSonochemistryGalliumAntibacterialPseudomonas aeruginosaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 725-730 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	C-dots Ga@C-dots Sonochemistry Gallium Antibacterial Pseudomonas aeruginosa Medicine (General) R5-920
spellingShingle	C-dots Ga@C-dots Sonochemistry Gallium Antibacterial Pseudomonas aeruginosa Medicine (General) R5-920 Kumar VB Natan M Jacobi G Porat Z Banin E Gedanken A Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa
description	Vijay Bhooshan Kumar,1 Michal Natan,2 Gila Jacobi,2 Ze’ev Porat,3,4 Ehud Banin,2 Aharon Gedanken1,5 1Department of Chemistry, 2Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan Institute for Nanotechnology and Advanced Materials Bar-Ilan University, Ramat Gan, 3Division of Chemistry, Nuclear Research Center-Negev, 4Institutes of Applied Research, Ben-Gurion University of the Negev, Be’er-Sheva, Israel; 5National Cheng Kung University, Department of Materials Science and Engineering, Tainan, Taiwan Abstract: The opportunistic pathogen Pseudomonas aeruginosa causes infections that are difficult to treat by antibiotic therapy. This research article reports on the synthesis of gallium (Ga) doped in carbon (C)-dots (Ga@C-dots) and their antimicrobial activity against free-living P. aeruginosa bacteria. The synthesis of Ga@C-dots was carried out by sonicating molten Ga (for 2.5 h) in polyethylene glycol-400, which acts as both a medium and carbon source. The resultant Ga@C-dots, having an average diameter of 9±2 nm, showed remarkably enhanced antibacterial activity compared with undoped C-dots. This was reflected by the much lower concentration of Ga doped within Ga@C-dots which was required for full inhibition of the bacterial growth. These results highlight the possibility of using Ga@C-dots as potential antimicrobial agents. Keywords: C-dots, Ga@C-dots, sonochemistry, gallium, antibacterial, Pseudomonas aeruginosa
format	article
author	Kumar VB Natan M Jacobi G Porat Z Banin E Gedanken A
author_facet	Kumar VB Natan M Jacobi G Porat Z Banin E Gedanken A
author_sort	Kumar VB
title	Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa
title_short	Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa
title_full	Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa
title_fullStr	Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa
title_full_unstemmed	Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa
title_sort	ga@c-dots as an antibacterial agent for the eradication of pseudomonas aeruginosa
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/54f6b83f63f44d3d8f5271b31fb9b01d
work_keys_str_mv	AT kumarvb gacdotsasanantibacterialagentfortheeradicationofpseudomonasaeruginosa AT natanm gacdotsasanantibacterialagentfortheeradicationofpseudomonasaeruginosa AT jacobig gacdotsasanantibacterialagentfortheeradicationofpseudomonasaeruginosa AT poratz gacdotsasanantibacterialagentfortheeradicationofpseudomonasaeruginosa AT banine gacdotsasanantibacterialagentfortheeradicationofpseudomonasaeruginosa AT gedankena gacdotsasanantibacterialagentfortheeradicationofpseudomonasaeruginosa
_version_	1718403496179400704

Ga@C-dots as an antibacterial agent for the eradication of Pseudomonas aeruginosa

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