Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears

Abstract There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds...

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Autores principales:	Sabrina Tartu, Roger Lille-Langøy, Trond R. Størseth, Sophie Bourgeon, Anders Brunsvik, Jon Aars, Anders Goksøyr, Bjørn Munro Jenssen, Anuschka Polder, Gregory W. Thiemann, Vidar Torget, Heli Routti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54f7116ded58440fa50c8e6af4c41b86
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spelling	oai:doaj.org-article:54f7116ded58440fa50c8e6af4c41b862021-12-02T11:40:20ZMultiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears10.1038/s41598-017-16820-52045-2322https://doaj.org/article/54f7116ded58440fa50c8e6af4c41b862017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-16820-5https://doaj.org/toc/2045-2322Abstract There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears (Ursus maritimus) from Svalbard, Norway (n = 112). We analyzed biomarkers of energy metabolism including the abundance profiles of nine lipid-related genes, fatty acid (FA) synthesis and elongation indices in adipose tissue, and concentrations of lipid-related variables in plasma (cholesterol, high-density lipoprotein, triglycerides). Furthermore, the plasma metabolome and lipidome were characterized by low molecular weight metabolites and lipid fingerprinting, respectively. Polychlorinated biphenyls, chlordanes, brominated diphenyl ethers and perfluoroalkyl substances were significantly related to biomarkers involved in lipid accumulation, FA metabolism, insulin utilization, and cholesterol homeostasis. Moreover, the effects of pollutants were measurable at the metabolome and lipidome levels. Our results indicate that several OHCs affect lipid biosynthesis and catabolism in female polar bears. Furthermore, these effects were more pronounced when combined with reduced sea ice extent and thickness, suggesting that climate-driven sea ice decline and OHCs have synergistic negative effects on polar bears.Sabrina TartuRoger Lille-LangøyTrond R. StørsethSophie BourgeonAnders BrunsvikJon AarsAnders GoksøyrBjørn Munro JenssenAnuschka PolderGregory W. ThiemannVidar TorgetHeli RouttiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sabrina Tartu Roger Lille-Langøy Trond R. Størseth Sophie Bourgeon Anders Brunsvik Jon Aars Anders Goksøyr Bjørn Munro Jenssen Anuschka Polder Gregory W. Thiemann Vidar Torget Heli Routti Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
description	Abstract There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears (Ursus maritimus) from Svalbard, Norway (n = 112). We analyzed biomarkers of energy metabolism including the abundance profiles of nine lipid-related genes, fatty acid (FA) synthesis and elongation indices in adipose tissue, and concentrations of lipid-related variables in plasma (cholesterol, high-density lipoprotein, triglycerides). Furthermore, the plasma metabolome and lipidome were characterized by low molecular weight metabolites and lipid fingerprinting, respectively. Polychlorinated biphenyls, chlordanes, brominated diphenyl ethers and perfluoroalkyl substances were significantly related to biomarkers involved in lipid accumulation, FA metabolism, insulin utilization, and cholesterol homeostasis. Moreover, the effects of pollutants were measurable at the metabolome and lipidome levels. Our results indicate that several OHCs affect lipid biosynthesis and catabolism in female polar bears. Furthermore, these effects were more pronounced when combined with reduced sea ice extent and thickness, suggesting that climate-driven sea ice decline and OHCs have synergistic negative effects on polar bears.
format	article
author	Sabrina Tartu Roger Lille-Langøy Trond R. Størseth Sophie Bourgeon Anders Brunsvik Jon Aars Anders Goksøyr Bjørn Munro Jenssen Anuschka Polder Gregory W. Thiemann Vidar Torget Heli Routti
author_facet	Sabrina Tartu Roger Lille-Langøy Trond R. Størseth Sophie Bourgeon Anders Brunsvik Jon Aars Anders Goksøyr Bjørn Munro Jenssen Anuschka Polder Gregory W. Thiemann Vidar Torget Heli Routti
author_sort	Sabrina Tartu
title	Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
title_short	Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
title_full	Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
title_fullStr	Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
title_full_unstemmed	Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
title_sort	multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/54f7116ded58440fa50c8e6af4c41b86
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Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears

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