Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance

Single cell whole-genome sequencing data harbors information about somatic genetic variation but is challenging to analyze. Here, the authors develop a spatial model to correct for allelic amplification imbalance and a somatic SNV genotyper SCAN-SNV for analyzing single cell DNA sequencing data.

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Autores principales:	Lovelace J. Luquette, Craig L. Bohrson, Max A. Sherman, Peter J. Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54f9af3e9c6f4cd1836227bb280a51be
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id	oai:doaj.org-article:54f9af3e9c6f4cd1836227bb280a51be
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spelling	oai:doaj.org-article:54f9af3e9c6f4cd1836227bb280a51be2021-12-02T16:50:57ZIdentification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance10.1038/s41467-019-11857-82041-1723https://doaj.org/article/54f9af3e9c6f4cd1836227bb280a51be2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11857-8https://doaj.org/toc/2041-1723Single cell whole-genome sequencing data harbors information about somatic genetic variation but is challenging to analyze. Here, the authors develop a spatial model to correct for allelic amplification imbalance and a somatic SNV genotyper SCAN-SNV for analyzing single cell DNA sequencing data.Lovelace J. LuquetteCraig L. BohrsonMax A. ShermanPeter J. ParkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lovelace J. Luquette Craig L. Bohrson Max A. Sherman Peter J. Park Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
description	Single cell whole-genome sequencing data harbors information about somatic genetic variation but is challenging to analyze. Here, the authors develop a spatial model to correct for allelic amplification imbalance and a somatic SNV genotyper SCAN-SNV for analyzing single cell DNA sequencing data.
format	article
author	Lovelace J. Luquette Craig L. Bohrson Max A. Sherman Peter J. Park
author_facet	Lovelace J. Luquette Craig L. Bohrson Max A. Sherman Peter J. Park
author_sort	Lovelace J. Luquette
title	Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
title_short	Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
title_full	Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
title_fullStr	Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
title_full_unstemmed	Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance
title_sort	identification of somatic mutations in single cell dna-seq using a spatial model of allelic imbalance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/54f9af3e9c6f4cd1836227bb280a51be
work_keys_str_mv	AT lovelacejluquette identificationofsomaticmutationsinsinglecelldnasequsingaspatialmodelofallelicimbalance AT craiglbohrson identificationofsomaticmutationsinsinglecelldnasequsingaspatialmodelofallelicimbalance AT maxasherman identificationofsomaticmutationsinsinglecelldnasequsingaspatialmodelofallelicimbalance AT peterjpark identificationofsomaticmutationsinsinglecelldnasequsingaspatialmodelofallelicimbalance
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Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance

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