Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance

Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance

Single cell whole-genome sequencing data harbors information about somatic genetic variation but is challenging to analyze. Here, the authors develop a spatial model to correct for allelic amplification imbalance and a somatic SNV genotyper SCAN-SNV for analyzing single cell DNA sequencing data.

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Detalles Bibliográficos
Autores principales: Lovelace J. Luquette, Craig L. Bohrson, Max A. Sherman, Peter J. Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/54f9af3e9c6f4cd1836227bb280a51be
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