Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods

Abstract Proteins often form chiral assembly structures on a biomembrane. However, the role of the chirality in the interaction with an achiral membrane is poorly understood. Here, we report how chirality of crescent-shaped protein rods changes their assembly and tubulation using meshless membrane s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Hiroshi Noguchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54ff21ebc24d4e70bed7dcf9798e28d9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54ff21ebc24d4e70bed7dcf9798e28d9
record_format	dspace
spelling	oai:doaj.org-article:54ff21ebc24d4e70bed7dcf9798e28d92021-12-02T16:08:28ZShape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods10.1038/s41598-019-48102-72045-2322https://doaj.org/article/54ff21ebc24d4e70bed7dcf9798e28d92019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48102-7https://doaj.org/toc/2045-2322Abstract Proteins often form chiral assembly structures on a biomembrane. However, the role of the chirality in the interaction with an achiral membrane is poorly understood. Here, we report how chirality of crescent-shaped protein rods changes their assembly and tubulation using meshless membrane simulations. The achiral rods deformed the membrane tube into an elliptical shape by stabilizing the edges of the ellipse. In contrast, the chiral rods formed a helical assembly that generated a cylindrical membrane tube with a constant radius in addition to the elliptical tube. This helical assembly could be further stabilized by the direct side-to-side attraction between the protein rods. The chirality also promotes the tubulation from a flat membrane. These results agree with experimental findings of the constant radius of membrane tubules induced by the Bin/Amphiphysin/Rvs (BAR) superfamily proteins.Hiroshi NoguchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroshi Noguchi Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
description	Abstract Proteins often form chiral assembly structures on a biomembrane. However, the role of the chirality in the interaction with an achiral membrane is poorly understood. Here, we report how chirality of crescent-shaped protein rods changes their assembly and tubulation using meshless membrane simulations. The achiral rods deformed the membrane tube into an elliptical shape by stabilizing the edges of the ellipse. In contrast, the chiral rods formed a helical assembly that generated a cylindrical membrane tube with a constant radius in addition to the elliptical tube. This helical assembly could be further stabilized by the direct side-to-side attraction between the protein rods. The chirality also promotes the tubulation from a flat membrane. These results agree with experimental findings of the constant radius of membrane tubules induced by the Bin/Amphiphysin/Rvs (BAR) superfamily proteins.
format	article
author	Hiroshi Noguchi
author_facet	Hiroshi Noguchi
author_sort	Hiroshi Noguchi
title	Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
title_short	Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
title_full	Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
title_fullStr	Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
title_full_unstemmed	Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
title_sort	shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/54ff21ebc24d4e70bed7dcf9798e28d9
work_keys_str_mv	AT hiroshinoguchi shapetransitionfromellipticaltocylindricalmembranetubesinducedbychiralcrescentshapedproteinrods
_version_	1718384468764393472

Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods

Ejemplares similares