Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand

Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand

Supinda Koonmee,1 Ongart Somintara,2 Piyapharom Intarawichian,1 Chaiwat Aphivatanasiri,1 Sakkarn Sangkhamanon,1 Suphawat Laohawiriyakamol,3 Rujira Panawattanakul,4 Phanchanut Mahantassanapong,5 Chayanoot Rattadilok,6 Piyarat Jeeravongpanich,7 Wilart Krongyute,8 Krisada Prachumrasee,9 Reza Alaghehban...

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Autores principales: Koonmee S, Somintara O, Intarawichian P, Aphivatanasiri C, Sangkhamanon S, Laohawiriyakamol S, Panawattanakul R, Mahantassanapong P, Rattadilok C, Jeeravongpanich P, Krongyute W, Prachumrasee K, Alaghehbandan R
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
breast cancer
biomarkers
pathum raksa
multidisciplinary teams
pre-analytical phase.
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/55004e3066d14b7fa9f1288a8e2f21c5
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spelling oai:doaj.org-article:55004e3066d14b7fa9f1288a8e2f21c52021-11-23T18:43:01ZPathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand1179-1322https://doaj.org/article/55004e3066d14b7fa9f1288a8e2f21c52021-11-01T00:00:00Zhttps://www.dovepress.com/pathum-raksa-project-addressing-disparity-in-breast-cancer-care-throug-peer-reviewed-fulltext-article-CMARhttps://doaj.org/toc/1179-1322Supinda Koonmee,1 Ongart Somintara,2 Piyapharom Intarawichian,1 Chaiwat Aphivatanasiri,1 Sakkarn Sangkhamanon,1 Suphawat Laohawiriyakamol,3 Rujira Panawattanakul,4 Phanchanut Mahantassanapong,5 Chayanoot Rattadilok,6 Piyarat Jeeravongpanich,7 Wilart Krongyute,8 Krisada Prachumrasee,9 Reza Alaghehbandan10 1Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 3Division of General Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand; 4Department of Surgery, Udonthani Hospital, Udonthani, Thailand; 5Department of Anatomical Pathology, Surin Hospital, Surin, Thailand; 6Department of Surgery, Nopparatrajathanee Hospital, Bangkok, Thailand; 7Anatomical Pathology Unit, Songkhla Hospital, Songkhla, Thailand; 8Department of Surgery, Fort Suranari Hospital, Nakhon Ratchasima, Thailand; 9The College of Local Administration, Khon Kaen University, Khon Kaen, Thailand; 10Department of Pathology, Faculty of Medicine, University of British Columbia, Royal Columbian Hospital, Vancouver, BC, CanadaCorrespondence: Chaiwat AphivatanasiriDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandEmail chaiap@kku.ac.thReza AlaghehbandanUniversity of British Columbia, Royal Columbian Hospital, Vancouver, BC, CanadaEmail reza.alagh@gmail.comPurpose: Breast cancer is a growing public health challenge in Thailand. Pathum Raksa project was launched in 2015, as a result of higher than expected rate of triple-negative breast cancers in Thai women. The purpose of this project was to identify the cause(s) and address the issue(s), hence improving the quality of breast cancer biomarker testing in Thailand.Materials and Methods: Nineteen hospitals across the country, with 902 breast cancer patients were enrolled in this study during 2015– 2020. The pre- and post-data from Pathum Raksa initiative was only available for Khon Kaen University (KKU) and Udonthani hospitals in Northeast Thailand. We developed a resource-stratified strategic plan that included designing a unique specimen container, forming multidisciplinary teams from the Surgery and Pathology Departments, and employing locally developed innovative technologies to optimize the entire process of breast cancer diagnostics and biomarker testing.Results: The rate of triple-negative breast cancers in KKU and Udonthani decreased 52.8% (p = 0.02) and 28.9% (p = 0.48), respectively. The rate of ER+ breast cancers in both hospitals increased 5% post-Pathum Raksa implementation. The rate of HER2-neu+ (score 3+) also increased in both hospitals (particularly an increased 65% rate in KKU). Luminal A/B cancers were the most common subtype in both KKU and Udonthani hospitals.Conclusion: Pathum Raksa project has significantly improved breast cancer biomarker testing in Thailand. As a result of this national innovation, false-negative rates of breast biomarkers have significantly decreased, resulting in improving prognosis, treatment, and survival of breast cancer women in Thailand.Keywords: breast cancer, biomarkers, Pathum Raksa, multidisciplinary teams, pre-analytical phaseKoonmee SSomintara OIntarawichian PAphivatanasiri CSangkhamanon SLaohawiriyakamol SPanawattanakul RMahantassanapong PRattadilok CJeeravongpanich PKrongyute WPrachumrasee KAlaghehbandan RDove Medical Pressarticlebreast cancerbiomarkerspathum raksamultidisciplinary teamspre-analytical phase.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Management and Research, Vol Volume 13, Pp 8737-8753 (2021)
institution DOAJ
collection DOAJ
language EN
topic breast cancer
biomarkers
pathum raksa
multidisciplinary teams
pre-analytical phase.
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle breast cancer
biomarkers
pathum raksa
multidisciplinary teams
pre-analytical phase.
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Koonmee S
Somintara O
Intarawichian P
Aphivatanasiri C
Sangkhamanon S
Laohawiriyakamol S
Panawattanakul R
Mahantassanapong P
Rattadilok C
Jeeravongpanich P
Krongyute W
Prachumrasee K
Alaghehbandan R
Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand
description Supinda Koonmee,1 Ongart Somintara,2 Piyapharom Intarawichian,1 Chaiwat Aphivatanasiri,1 Sakkarn Sangkhamanon,1 Suphawat Laohawiriyakamol,3 Rujira Panawattanakul,4 Phanchanut Mahantassanapong,5 Chayanoot Rattadilok,6 Piyarat Jeeravongpanich,7 Wilart Krongyute,8 Krisada Prachumrasee,9 Reza Alaghehbandan10 1Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 3Division of General Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand; 4Department of Surgery, Udonthani Hospital, Udonthani, Thailand; 5Department of Anatomical Pathology, Surin Hospital, Surin, Thailand; 6Department of Surgery, Nopparatrajathanee Hospital, Bangkok, Thailand; 7Anatomical Pathology Unit, Songkhla Hospital, Songkhla, Thailand; 8Department of Surgery, Fort Suranari Hospital, Nakhon Ratchasima, Thailand; 9The College of Local Administration, Khon Kaen University, Khon Kaen, Thailand; 10Department of Pathology, Faculty of Medicine, University of British Columbia, Royal Columbian Hospital, Vancouver, BC, CanadaCorrespondence: Chaiwat AphivatanasiriDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandEmail chaiap@kku.ac.thReza AlaghehbandanUniversity of British Columbia, Royal Columbian Hospital, Vancouver, BC, CanadaEmail reza.alagh@gmail.comPurpose: Breast cancer is a growing public health challenge in Thailand. Pathum Raksa project was launched in 2015, as a result of higher than expected rate of triple-negative breast cancers in Thai women. The purpose of this project was to identify the cause(s) and address the issue(s), hence improving the quality of breast cancer biomarker testing in Thailand.Materials and Methods: Nineteen hospitals across the country, with 902 breast cancer patients were enrolled in this study during 2015– 2020. The pre- and post-data from Pathum Raksa initiative was only available for Khon Kaen University (KKU) and Udonthani hospitals in Northeast Thailand. We developed a resource-stratified strategic plan that included designing a unique specimen container, forming multidisciplinary teams from the Surgery and Pathology Departments, and employing locally developed innovative technologies to optimize the entire process of breast cancer diagnostics and biomarker testing.Results: The rate of triple-negative breast cancers in KKU and Udonthani decreased 52.8% (p = 0.02) and 28.9% (p = 0.48), respectively. The rate of ER+ breast cancers in both hospitals increased 5% post-Pathum Raksa implementation. The rate of HER2-neu+ (score 3+) also increased in both hospitals (particularly an increased 65% rate in KKU). Luminal A/B cancers were the most common subtype in both KKU and Udonthani hospitals.Conclusion: Pathum Raksa project has significantly improved breast cancer biomarker testing in Thailand. As a result of this national innovation, false-negative rates of breast biomarkers have significantly decreased, resulting in improving prognosis, treatment, and survival of breast cancer women in Thailand.Keywords: breast cancer, biomarkers, Pathum Raksa, multidisciplinary teams, pre-analytical phase
format article
author Koonmee S
Somintara O
Intarawichian P
Aphivatanasiri C
Sangkhamanon S
Laohawiriyakamol S
Panawattanakul R
Mahantassanapong P
Rattadilok C
Jeeravongpanich P
Krongyute W
Prachumrasee K
Alaghehbandan R
author_facet Koonmee S
Somintara O
Intarawichian P
Aphivatanasiri C
Sangkhamanon S
Laohawiriyakamol S
Panawattanakul R
Mahantassanapong P
Rattadilok C
Jeeravongpanich P
Krongyute W
Prachumrasee K
Alaghehbandan R
author_sort Koonmee S
title Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand
title_short Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand
title_full Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand
title_fullStr Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand
title_full_unstemmed Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand
title_sort pathum raksa project: addressing disparity in breast cancer care through national innovation in thailand
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/55004e3066d14b7fa9f1288a8e2f21c5
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