Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs

Abstract One third of multiple trauma patients present abnormal echocardiographic (ECHO) findings. Therefore, ECHO diagnostic after trauma is indicated in case of hemodynamic instability, shock, after chest trauma and after cardiac arrest. 20 male pigs underwent multiple trauma. Blood samples were c...

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Autores principales:	Birte Weber, Ina Lackner, Meike Baur, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Michel Teuben, Hans-Christoph Pape, Armin Imhof, Miriam Lipiski, Nikola Cesarovic, Miriam Kalbitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/550287e919be494e9d2086602d945174
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spelling	oai:doaj.org-article:550287e919be494e9d2086602d9451742021-12-02T15:23:02ZEarly myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs10.1038/s41598-020-80409-82045-2322https://doaj.org/article/550287e919be494e9d2086602d9451742021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80409-8https://doaj.org/toc/2045-2322Abstract One third of multiple trauma patients present abnormal echocardiographic (ECHO) findings. Therefore, ECHO diagnostic after trauma is indicated in case of hemodynamic instability, shock, after chest trauma and after cardiac arrest. 20 male pigs underwent multiple trauma. Blood samples were collected 4 and 6 h after trauma and concentrations of heart-type fatty acid binding protein (HFABP) as a biomarker for EMD were measured. Myocardial damage was evaluated by scoring Hematoxylin–Eosin stained sections. At baseline, 3 and 6 h after trauma, transesophageal ECHO (TOE) was performed, invasive arterial and left ventricular blood pressure were measured to evaluate the cardiac function after multiple trauma. Systemic HFABP concentrations were elevated, furthermore heart injury score in multiple trauma animals was increased determining EMD. A significant decrease of blood pressure in combination with a consecutive rise of heart frequency was observed. Ongoing depression of mean arterial pressure and diastolic blood pressure were accompanied by changes in ECHO-parameters indicating diastolic and systolic dysfunction. Furthermore, a valvular dysfunction was detected. In this study complex myocardial and valvular impairment after multiple trauma in pigs has been observed. Therefore, detection of EMD and progressive valvular dysfunction might be crucial and therapeutically relevant.Birte WeberIna LacknerMeike BaurFlorian GebhardRoman PfeiferPaolo CinelliSascha HalvachizadehMichel TeubenHans-Christoph PapeArmin ImhofMiriam LipiskiNikola CesarovicMiriam KalbitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Birte Weber Ina Lackner Meike Baur Florian Gebhard Roman Pfeifer Paolo Cinelli Sascha Halvachizadeh Michel Teuben Hans-Christoph Pape Armin Imhof Miriam Lipiski Nikola Cesarovic Miriam Kalbitz Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs
description	Abstract One third of multiple trauma patients present abnormal echocardiographic (ECHO) findings. Therefore, ECHO diagnostic after trauma is indicated in case of hemodynamic instability, shock, after chest trauma and after cardiac arrest. 20 male pigs underwent multiple trauma. Blood samples were collected 4 and 6 h after trauma and concentrations of heart-type fatty acid binding protein (HFABP) as a biomarker for EMD were measured. Myocardial damage was evaluated by scoring Hematoxylin–Eosin stained sections. At baseline, 3 and 6 h after trauma, transesophageal ECHO (TOE) was performed, invasive arterial and left ventricular blood pressure were measured to evaluate the cardiac function after multiple trauma. Systemic HFABP concentrations were elevated, furthermore heart injury score in multiple trauma animals was increased determining EMD. A significant decrease of blood pressure in combination with a consecutive rise of heart frequency was observed. Ongoing depression of mean arterial pressure and diastolic blood pressure were accompanied by changes in ECHO-parameters indicating diastolic and systolic dysfunction. Furthermore, a valvular dysfunction was detected. In this study complex myocardial and valvular impairment after multiple trauma in pigs has been observed. Therefore, detection of EMD and progressive valvular dysfunction might be crucial and therapeutically relevant.
format	article
author	Birte Weber Ina Lackner Meike Baur Florian Gebhard Roman Pfeifer Paolo Cinelli Sascha Halvachizadeh Michel Teuben Hans-Christoph Pape Armin Imhof Miriam Lipiski Nikola Cesarovic Miriam Kalbitz
author_facet	Birte Weber Ina Lackner Meike Baur Florian Gebhard Roman Pfeifer Paolo Cinelli Sascha Halvachizadeh Michel Teuben Hans-Christoph Pape Armin Imhof Miriam Lipiski Nikola Cesarovic Miriam Kalbitz
author_sort	Birte Weber
title	Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs
title_short	Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs
title_full	Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs
title_fullStr	Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs
title_full_unstemmed	Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs
title_sort	early myocardial damage (emd) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/550287e919be494e9d2086602d945174
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Early myocardial damage (EMD) and valvular insufficiency result in impaired cardiac function after multiple trauma in pigs

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