Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation

Abstract Immunosuppressive therapy can decrease rejection episodes and increase the risk of severe and fatal infections in heart transplantation (HT) recipients. Immunosuppressive therapy can also decrease the absolute lymphocyte count (ALC), but the relationship between early post-transplant ALC an...

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Autores principales:	Minjae Yoon, Jaewon Oh, Kyeong-Hyeon Chun, Chan Joo Lee, Seok-Min Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/550504f146ab437abc7137bee8ec93e6
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spelling	oai:doaj.org-article:550504f146ab437abc7137bee8ec93e62021-12-02T14:01:35ZPost-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation10.1038/s41598-020-80790-42045-2322https://doaj.org/article/550504f146ab437abc7137bee8ec93e62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80790-4https://doaj.org/toc/2045-2322Abstract Immunosuppressive therapy can decrease rejection episodes and increase the risk of severe and fatal infections in heart transplantation (HT) recipients. Immunosuppressive therapy can also decrease the absolute lymphocyte count (ALC), but the relationship between early post-transplant ALC and early cytomegalovirus (CMV) infection is largely unknown, especially in HT. We retrospectively analyzed 58 HT recipients who tested positive for CMV IgG antibody and received basiliximab induction therapy. We collected preoperative and 2-month postoperative data on ALC and CMV load. The CMV load > 1200 IU/mL was used as the cutoff value to define early CMV infection. Post-transplant lymphopenia was defined as an ALC of < 500 cells/μL at postoperative day (POD) #7. On POD #7, 29 (50.0%) patients had post-transplant lymphopenia and 29 (50.0%) patients did not. The incidence of CMV infection within 1 or 2 months of HT was higher in the post-transplant lymphopenia group than in the non-lymphopenia group (82.8% vs. 48.3%, P = 0.013; 89.7% vs. 65.5%, P = 0.028, respectively). ALC < 500 cells/μL on POD #7 was an independent risk factor for early CMV infection within 1 month of HT (odds ratio, 4.14; 95% confidence interval, 1.16–14.77; P = 0.029). A low ALC after HT was associated with a high risk of early CMV infection. Post-transplant ALC monitoring is simple and inexpensive and can help identify patients at high risk of early CMV infection.Minjae YoonJaewon OhKyeong-Hyeon ChunChan Joo LeeSeok-Min KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Minjae Yoon Jaewon Oh Kyeong-Hyeon Chun Chan Joo Lee Seok-Min Kang Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation
description	Abstract Immunosuppressive therapy can decrease rejection episodes and increase the risk of severe and fatal infections in heart transplantation (HT) recipients. Immunosuppressive therapy can also decrease the absolute lymphocyte count (ALC), but the relationship between early post-transplant ALC and early cytomegalovirus (CMV) infection is largely unknown, especially in HT. We retrospectively analyzed 58 HT recipients who tested positive for CMV IgG antibody and received basiliximab induction therapy. We collected preoperative and 2-month postoperative data on ALC and CMV load. The CMV load > 1200 IU/mL was used as the cutoff value to define early CMV infection. Post-transplant lymphopenia was defined as an ALC of < 500 cells/μL at postoperative day (POD) #7. On POD #7, 29 (50.0%) patients had post-transplant lymphopenia and 29 (50.0%) patients did not. The incidence of CMV infection within 1 or 2 months of HT was higher in the post-transplant lymphopenia group than in the non-lymphopenia group (82.8% vs. 48.3%, P = 0.013; 89.7% vs. 65.5%, P = 0.028, respectively). ALC < 500 cells/μL on POD #7 was an independent risk factor for early CMV infection within 1 month of HT (odds ratio, 4.14; 95% confidence interval, 1.16–14.77; P = 0.029). A low ALC after HT was associated with a high risk of early CMV infection. Post-transplant ALC monitoring is simple and inexpensive and can help identify patients at high risk of early CMV infection.
format	article
author	Minjae Yoon Jaewon Oh Kyeong-Hyeon Chun Chan Joo Lee Seok-Min Kang
author_facet	Minjae Yoon Jaewon Oh Kyeong-Hyeon Chun Chan Joo Lee Seok-Min Kang
author_sort	Minjae Yoon
title	Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation
title_short	Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation
title_full	Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation
title_fullStr	Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation
title_full_unstemmed	Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation
title_sort	post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/550504f146ab437abc7137bee8ec93e6
work_keys_str_mv	AT minjaeyoon posttransplantabsolutelymphocytecountpredictsearlycytomegalovirusinfectionafterhearttransplantation AT jaewonoh posttransplantabsolutelymphocytecountpredictsearlycytomegalovirusinfectionafterhearttransplantation AT kyeonghyeonchun posttransplantabsolutelymphocytecountpredictsearlycytomegalovirusinfectionafterhearttransplantation AT chanjoolee posttransplantabsolutelymphocytecountpredictsearlycytomegalovirusinfectionafterhearttransplantation AT seokminkang posttransplantabsolutelymphocytecountpredictsearlycytomegalovirusinfectionafterhearttransplantation
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Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation

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