Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity

C-C bond scission of unstrained cycloketones with high regioselectivity is a challenging synthetic task. Here, the authors show a facile C-C cleavage of cyclohexanones and cyclopentanones with unusual selectivity under mild conditions with the aid of an in situ formed side-chain aryl radical.

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Autores principales:	Mingyang Wang, Man Li, Shan Yang, Xiao-Song Xue, Xinxin Wu, Chen Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55051764b1994bef9084f3bc8a817022
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spelling	oai:doaj.org-article:55051764b1994bef9084f3bc8a8170222021-12-02T16:49:45ZRadical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity10.1038/s41467-020-14435-52041-1723https://doaj.org/article/55051764b1994bef9084f3bc8a8170222020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14435-5https://doaj.org/toc/2041-1723C-C bond scission of unstrained cycloketones with high regioselectivity is a challenging synthetic task. Here, the authors show a facile C-C cleavage of cyclohexanones and cyclopentanones with unusual selectivity under mild conditions with the aid of an in situ formed side-chain aryl radical.Mingyang WangMan LiShan YangXiao-Song XueXinxin WuChen ZhuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingyang Wang Man Li Shan Yang Xiao-Song Xue Xinxin Wu Chen Zhu Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity
description	C-C bond scission of unstrained cycloketones with high regioselectivity is a challenging synthetic task. Here, the authors show a facile C-C cleavage of cyclohexanones and cyclopentanones with unusual selectivity under mild conditions with the aid of an in situ formed side-chain aryl radical.
format	article
author	Mingyang Wang Man Li Shan Yang Xiao-Song Xue Xinxin Wu Chen Zhu
author_facet	Mingyang Wang Man Li Shan Yang Xiao-Song Xue Xinxin Wu Chen Zhu
author_sort	Mingyang Wang
title	Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity
title_short	Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity
title_full	Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity
title_fullStr	Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity
title_full_unstemmed	Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity
title_sort	radical-mediated c-c cleavage of unstrained cycloketones and dft study for unusual regioselectivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/55051764b1994bef9084f3bc8a817022
work_keys_str_mv	AT mingyangwang radicalmediatedcccleavageofunstrainedcycloketonesanddftstudyforunusualregioselectivity AT manli radicalmediatedcccleavageofunstrainedcycloketonesanddftstudyforunusualregioselectivity AT shanyang radicalmediatedcccleavageofunstrainedcycloketonesanddftstudyforunusualregioselectivity AT xiaosongxue radicalmediatedcccleavageofunstrainedcycloketonesanddftstudyforunusualregioselectivity AT xinxinwu radicalmediatedcccleavageofunstrainedcycloketonesanddftstudyforunusualregioselectivity AT chenzhu radicalmediatedcccleavageofunstrainedcycloketonesanddftstudyforunusualregioselectivity
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Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity

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