Expert consensus. Effect of antihypertensive therapy on cognitive functions

Arterial hypertension (AH) is the major modifiable risk factor for cognitive impairment (CI), including dementia, CI in cerebrovascular and neurodegenerative diseases, including Alzheimers disease. By 2050, the number of people with dementia will approximately 3 times increase due to the aging popul...

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Autores principales:	Olga D. Ostroumova, Vladimir A. Parfenov, Tatiana M. Ostroumova, Nikolay N. Yakhno, Irina E. Chazova, Anna N. Bogolepova, Albert S. Galyavich, Liudmila A. Geraskina, Andrey Iu. Emelin, Vladimir V. Zakharov, Oxana A. Kislyak, Aleksei A. Kulesh, Oleg S. Levin, Valery I. Podzolkov, Elena V. Privalova, Evgenia V. Shikh
Formato:	article
Lenguaje:	RU
Publicado:	IP Morozov P.V. 2021
Materias:	arterial hypertension cognitive functions cognitive impairment dementia antihypertensive therapy antihypertensive drugs Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/5509222bbaef4139880fb9e8df9a32f2
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spelling	oai:doaj.org-article:5509222bbaef4139880fb9e8df9a32f22021-11-30T16:09:16ZExpert consensus. Effect of antihypertensive therapy on cognitive functions2075-082X2542-218910.26442/2075082X.2021.1.200575https://doaj.org/article/5509222bbaef4139880fb9e8df9a32f22021-03-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/65106/47925https://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189Arterial hypertension (AH) is the major modifiable risk factor for cognitive impairment (CI), including dementia, CI in cerebrovascular and neurodegenerative diseases, including Alzheimers disease. By 2050, the number of people with dementia will approximately 3 times increase due to the aging population and limited opportunities for drug prevention and treatment of severe CI. In connection with the above, it seems necessary to create an expert consensus, which would summarize the evidence-based medicine data available to date on the effect of antihypertensive therapy (AHT) on cognitive function (CF). In the expert consensus, the data of prospective randomized clinical trials, observational and population studies, meta-analyzes on the effect of AHT on the risk of dementia and CI progression, including certain CF, were summarized and analyzed. The consensus considers the effect of antihypertensive drugs (AHD) on various cognitive domains. Literature data give evidence that AHT reduces the risk for dementia, including vascular dementia, reduces the risk of for dementia in Alzheimers disease, as well as reduces the risk and can prevent the progression of non-dementia CI. The effect of AHT on various CF has been little studied. Most meta-analyzes did not reveal the benefits of any class of AHD; however, one study demonstrated the advantage of angiotensin receptor blockers, while another study diuretics. The consensus emphasizes that, given the high incidence of AH in the general population, AHT may be one of the most effective ways to prevent CI or delay CI progression. The effect of different classes of AHD on CF requires further study. It is necessary to conduct a larger number of well-designed randomized clinical trials that would assess the state of executive functions in patients with AH.Olga D. OstroumovaVladimir A. ParfenovTatiana M. OstroumovaNikolay N. YakhnoIrina E. ChazovaAnna N. BogolepovaAlbert S. GalyavichLiudmila A. GeraskinaAndrey Iu. EmelinVladimir V. ZakharovOxana A. KislyakAleksei A. KuleshOleg S. LevinValery I. PodzolkovElena V. PrivalovaEvgenia V. ShikhIP Morozov P.V.articlearterial hypertensioncognitive functionscognitive impairmentdementiaantihypertensive therapyantihypertensive drugsDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 18, Iss 1, Pp 5-12 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	arterial hypertension cognitive functions cognitive impairment dementia antihypertensive therapy antihypertensive drugs Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	arterial hypertension cognitive functions cognitive impairment dementia antihypertensive therapy antihypertensive drugs Diseases of the circulatory (Cardiovascular) system RC666-701 Olga D. Ostroumova Vladimir A. Parfenov Tatiana M. Ostroumova Nikolay N. Yakhno Irina E. Chazova Anna N. Bogolepova Albert S. Galyavich Liudmila A. Geraskina Andrey Iu. Emelin Vladimir V. Zakharov Oxana A. Kislyak Aleksei A. Kulesh Oleg S. Levin Valery I. Podzolkov Elena V. Privalova Evgenia V. Shikh Expert consensus. Effect of antihypertensive therapy on cognitive functions
description	Arterial hypertension (AH) is the major modifiable risk factor for cognitive impairment (CI), including dementia, CI in cerebrovascular and neurodegenerative diseases, including Alzheimers disease. By 2050, the number of people with dementia will approximately 3 times increase due to the aging population and limited opportunities for drug prevention and treatment of severe CI. In connection with the above, it seems necessary to create an expert consensus, which would summarize the evidence-based medicine data available to date on the effect of antihypertensive therapy (AHT) on cognitive function (CF). In the expert consensus, the data of prospective randomized clinical trials, observational and population studies, meta-analyzes on the effect of AHT on the risk of dementia and CI progression, including certain CF, were summarized and analyzed. The consensus considers the effect of antihypertensive drugs (AHD) on various cognitive domains. Literature data give evidence that AHT reduces the risk for dementia, including vascular dementia, reduces the risk of for dementia in Alzheimers disease, as well as reduces the risk and can prevent the progression of non-dementia CI. The effect of AHT on various CF has been little studied. Most meta-analyzes did not reveal the benefits of any class of AHD; however, one study demonstrated the advantage of angiotensin receptor blockers, while another study diuretics. The consensus emphasizes that, given the high incidence of AH in the general population, AHT may be one of the most effective ways to prevent CI or delay CI progression. The effect of different classes of AHD on CF requires further study. It is necessary to conduct a larger number of well-designed randomized clinical trials that would assess the state of executive functions in patients with AH.
format	article
author	Olga D. Ostroumova Vladimir A. Parfenov Tatiana M. Ostroumova Nikolay N. Yakhno Irina E. Chazova Anna N. Bogolepova Albert S. Galyavich Liudmila A. Geraskina Andrey Iu. Emelin Vladimir V. Zakharov Oxana A. Kislyak Aleksei A. Kulesh Oleg S. Levin Valery I. Podzolkov Elena V. Privalova Evgenia V. Shikh
author_facet	Olga D. Ostroumova Vladimir A. Parfenov Tatiana M. Ostroumova Nikolay N. Yakhno Irina E. Chazova Anna N. Bogolepova Albert S. Galyavich Liudmila A. Geraskina Andrey Iu. Emelin Vladimir V. Zakharov Oxana A. Kislyak Aleksei A. Kulesh Oleg S. Levin Valery I. Podzolkov Elena V. Privalova Evgenia V. Shikh
author_sort	Olga D. Ostroumova
title	Expert consensus. Effect of antihypertensive therapy on cognitive functions
title_short	Expert consensus. Effect of antihypertensive therapy on cognitive functions
title_full	Expert consensus. Effect of antihypertensive therapy on cognitive functions
title_fullStr	Expert consensus. Effect of antihypertensive therapy on cognitive functions
title_full_unstemmed	Expert consensus. Effect of antihypertensive therapy on cognitive functions
title_sort	expert consensus. effect of antihypertensive therapy on cognitive functions
publisher	IP Morozov P.V.
publishDate	2021
url	https://doaj.org/article/5509222bbaef4139880fb9e8df9a32f2
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Expert consensus. Effect of antihypertensive therapy on cognitive functions

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