Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia

Background: Preeclampsia [PE] is one of the commonest medical emergencies. It had high morbidity for the mother and her infant. Early diagnosis could reduce such morbidity. Aim of the work: To evaluate the role of maternal serum placental protein [PP13] levels and uterine artery Doppler in early p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marwa El-hassab, Rashed Mohamed Rashed, Magdy Elghannam, Alaa Eldin Megahed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	preeclampsia placental protein-13 uterine artery doppler prediction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/550dbd79ff7c4a4da3633f5df0151c22
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:550dbd79ff7c4a4da3633f5df0151c22
record_format	dspace
spelling	oai:doaj.org-article:550dbd79ff7c4a4da3633f5df0151c222021-12-02T14:02:00ZPredictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia2636-41742682-378010.21608/ijma.2020.22342.1081https://doaj.org/article/550dbd79ff7c4a4da3633f5df0151c222020-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_93181_5acfbe9a427fed54eefaa61668ca0fcb.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Preeclampsia [PE] is one of the commonest medical emergencies. It had high morbidity for the mother and her infant. Early diagnosis could reduce such morbidity. Aim of the work: To evaluate the role of maternal serum placental protein [PP13] levels and uterine artery Doppler in early prediction and prognosis of preeclampsia. Patients and Methods: The study included 60 pregnant women in their first and early second trimester with high risk for preeclampsia. Patients were divided into three groups: control, mild and sever preeclampsia. All were subjected to proper history taking, clinical and obstetrical examination, laboratory investigations and ultrasound examination. Results: Cesarean delivery was significantly increased in preeclampsia compared to controls [55% of mild and 20% of severe disease compared to 15% of controls]. Both uterine artery resistance index [RI] and pulsatility index [PI] were significantly increased in PE when compared to control and in severe when compared to mild PE groups. Finally, PP13 was significantly decreased in patients with severe PE [171.7±35.9] when compared to mild PE [213.1±41.8] or control group [254.8±51.1]. In addition, there was significant decrease in cases with mild PE when compared to control group. Finally, there was inverse [negative], moderate and statistically significant correlation between PP-13 from one side and each of systolic BP, diastolic BP, uterine artery RI and PI. In addition, both RI and PI were proportionally correlated with PI and RI. Conclusion: The present study showed that PP13 combined with PI or RI can predict PE with a good sensitivity and specificity.Marwa El-hassabRashed Mohamed RashedMagdy ElghannamAlaa Eldin MegahedAl-Azhar University, Faculty of Medicine (Damietta)articlepreeclampsiaplacental protein-13uterine arterydopplerpredictionMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 3, Pp 528-534 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	preeclampsia placental protein-13 uterine artery doppler prediction Medicine (General) R5-920
spellingShingle	preeclampsia placental protein-13 uterine artery doppler prediction Medicine (General) R5-920 Marwa El-hassab Rashed Mohamed Rashed Magdy Elghannam Alaa Eldin Megahed Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia
description	Background: Preeclampsia [PE] is one of the commonest medical emergencies. It had high morbidity for the mother and her infant. Early diagnosis could reduce such morbidity. Aim of the work: To evaluate the role of maternal serum placental protein [PP13] levels and uterine artery Doppler in early prediction and prognosis of preeclampsia. Patients and Methods: The study included 60 pregnant women in their first and early second trimester with high risk for preeclampsia. Patients were divided into three groups: control, mild and sever preeclampsia. All were subjected to proper history taking, clinical and obstetrical examination, laboratory investigations and ultrasound examination. Results: Cesarean delivery was significantly increased in preeclampsia compared to controls [55% of mild and 20% of severe disease compared to 15% of controls]. Both uterine artery resistance index [RI] and pulsatility index [PI] were significantly increased in PE when compared to control and in severe when compared to mild PE groups. Finally, PP13 was significantly decreased in patients with severe PE [171.7±35.9] when compared to mild PE [213.1±41.8] or control group [254.8±51.1]. In addition, there was significant decrease in cases with mild PE when compared to control group. Finally, there was inverse [negative], moderate and statistically significant correlation between PP-13 from one side and each of systolic BP, diastolic BP, uterine artery RI and PI. In addition, both RI and PI were proportionally correlated with PI and RI. Conclusion: The present study showed that PP13 combined with PI or RI can predict PE with a good sensitivity and specificity.
format	article
author	Marwa El-hassab Rashed Mohamed Rashed Magdy Elghannam Alaa Eldin Megahed
author_facet	Marwa El-hassab Rashed Mohamed Rashed Magdy Elghannam Alaa Eldin Megahed
author_sort	Marwa El-hassab
title	Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia
title_short	Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia
title_full	Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia
title_fullStr	Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia
title_full_unstemmed	Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia
title_sort	predictive value of both serum placental protein-13 level and uterine artery doppler for prediction of pre-eclampsia
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/550dbd79ff7c4a4da3633f5df0151c22
work_keys_str_mv	AT marwaelhassab predictivevalueofbothserumplacentalprotein13levelanduterinearterydopplerforpredictionofpreeclampsia AT rashedmohamedrashed predictivevalueofbothserumplacentalprotein13levelanduterinearterydopplerforpredictionofpreeclampsia AT magdyelghannam predictivevalueofbothserumplacentalprotein13levelanduterinearterydopplerforpredictionofpreeclampsia AT alaaeldinmegahed predictivevalueofbothserumplacentalprotein13levelanduterinearterydopplerforpredictionofpreeclampsia
_version_	1718392079305932800

Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia

Ejemplares similares