Wars2 is a determinant of angiogenesis
Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggest...
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Nature Portfolio
2016
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oai:doaj.org-article:550ec9cd37e7417c90bb6b8603a4479c2021-12-02T14:39:12ZWars2 is a determinant of angiogenesis10.1038/ncomms120612041-1723https://doaj.org/article/550ec9cd37e7417c90bb6b8603a4479c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12061https://doaj.org/toc/2041-1723Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis.Mao WangPatrick SipsEster KhinMaxime RotivalXiming SunRizwan AhmedAnissa Anindya WidjajaSebastian SchaferPermeen YusoffPervinder Kaur ChoksiNicole Shi Jie KoManvendra K. SinghDavid EpsteinYuguang GuanJosef HouštěkTomas MracekHana NuskovaBrittney MikellJessie TanFrancesco PesceFrantisek KolarLeonardo BottoloMassimiliano ManciniNorbert HubnerMichal PravenecEnrico PetrettoCalum MacRaeStuart A CookNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mao Wang Patrick Sips Ester Khin Maxime Rotival Ximing Sun Rizwan Ahmed Anissa Anindya Widjaja Sebastian Schafer Permeen Yusoff Pervinder Kaur Choksi Nicole Shi Jie Ko Manvendra K. Singh David Epstein Yuguang Guan Josef Houštěk Tomas Mracek Hana Nuskova Brittney Mikell Jessie Tan Francesco Pesce Frantisek Kolar Leonardo Bottolo Massimiliano Mancini Norbert Hubner Michal Pravenec Enrico Petretto Calum MacRae Stuart A Cook Wars2 is a determinant of angiogenesis |
| description |
Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis. |
| format |
article |
| author |
Mao Wang Patrick Sips Ester Khin Maxime Rotival Ximing Sun Rizwan Ahmed Anissa Anindya Widjaja Sebastian Schafer Permeen Yusoff Pervinder Kaur Choksi Nicole Shi Jie Ko Manvendra K. Singh David Epstein Yuguang Guan Josef Houštěk Tomas Mracek Hana Nuskova Brittney Mikell Jessie Tan Francesco Pesce Frantisek Kolar Leonardo Bottolo Massimiliano Mancini Norbert Hubner Michal Pravenec Enrico Petretto Calum MacRae Stuart A Cook |
| author_facet |
Mao Wang Patrick Sips Ester Khin Maxime Rotival Ximing Sun Rizwan Ahmed Anissa Anindya Widjaja Sebastian Schafer Permeen Yusoff Pervinder Kaur Choksi Nicole Shi Jie Ko Manvendra K. Singh David Epstein Yuguang Guan Josef Houštěk Tomas Mracek Hana Nuskova Brittney Mikell Jessie Tan Francesco Pesce Frantisek Kolar Leonardo Bottolo Massimiliano Mancini Norbert Hubner Michal Pravenec Enrico Petretto Calum MacRae Stuart A Cook |
| author_sort |
Mao Wang |
| title |
Wars2 is a determinant of angiogenesis |
| title_short |
Wars2 is a determinant of angiogenesis |
| title_full |
Wars2 is a determinant of angiogenesis |
| title_fullStr |
Wars2 is a determinant of angiogenesis |
| title_full_unstemmed |
Wars2 is a determinant of angiogenesis |
| title_sort |
wars2 is a determinant of angiogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/550ec9cd37e7417c90bb6b8603a4479c |
| work_keys_str_mv |
AT maowang wars2isadeterminantofangiogenesis AT patricksips wars2isadeterminantofangiogenesis AT esterkhin wars2isadeterminantofangiogenesis AT maximerotival wars2isadeterminantofangiogenesis AT ximingsun wars2isadeterminantofangiogenesis AT rizwanahmed wars2isadeterminantofangiogenesis AT anissaanindyawidjaja wars2isadeterminantofangiogenesis AT sebastianschafer wars2isadeterminantofangiogenesis AT permeenyusoff wars2isadeterminantofangiogenesis AT pervinderkaurchoksi wars2isadeterminantofangiogenesis AT nicoleshijieko wars2isadeterminantofangiogenesis AT manvendraksingh wars2isadeterminantofangiogenesis AT davidepstein wars2isadeterminantofangiogenesis AT yuguangguan wars2isadeterminantofangiogenesis AT josefhoustek wars2isadeterminantofangiogenesis AT tomasmracek wars2isadeterminantofangiogenesis AT hananuskova wars2isadeterminantofangiogenesis AT brittneymikell wars2isadeterminantofangiogenesis AT jessietan wars2isadeterminantofangiogenesis AT francescopesce wars2isadeterminantofangiogenesis AT frantisekkolar wars2isadeterminantofangiogenesis AT leonardobottolo wars2isadeterminantofangiogenesis AT massimilianomancini wars2isadeterminantofangiogenesis AT norberthubner wars2isadeterminantofangiogenesis AT michalpravenec wars2isadeterminantofangiogenesis AT enricopetretto wars2isadeterminantofangiogenesis AT calummacrae wars2isadeterminantofangiogenesis AT stuartacook wars2isadeterminantofangiogenesis |
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1718390713986580480 |