Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma

Xu Zhang,1,&ast; Shuai Ping,2,&ast; Anni Wang,3 Can Li,4 Rui Zhang,5 Zimu Song,3 Caibin Gao,3 Feng Wang6 1Department of Neurosurgery, Baoding No.1 Central Hospital, Baoding, People’s Republic of China; 2Department of Orthopaedics, Liyuan Hospital, Tongji Medical College, Huazhong University...

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Autores principales:	Zhang X, Ping S, Wang A, Li C, Zhang R, Song Z, Gao C, Wang F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	glioma prognosis immune-related gene pairs tcga cgga Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/55106287be0e4f809cd6ecff8faa94cf
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spelling	oai:doaj.org-article:55106287be0e4f809cd6ecff8faa94cf2021-11-23T18:43:01ZDevelopment and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma1178-7074https://doaj.org/article/55106287be0e4f809cd6ecff8faa94cf2021-11-01T00:00:00Zhttps://www.dovepress.com/development-and-validation-of-an-immune-related-gene-pairs-signature-i-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Xu Zhang,1,&ast; Shuai Ping,2,&ast; Anni Wang,3 Can Li,4 Rui Zhang,5 Zimu Song,3 Caibin Gao,3 Feng Wang6 1Department of Neurosurgery, Baoding No.1 Central Hospital, Baoding, People’s Republic of China; 2Department of Orthopaedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 4Department of Neurosurgery, Chengdu Sixth People’s Hospital, Chengdu, People’s Republic of China; 5Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, People’s Republic of China; 6Department of Neurosurgery, People’s Hospital of Ningxia Hui Autonomous Region Yinchuan, Yinchuan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Feng Wang Email nxwwang@163.comBackground: Gliomas are prevalent primary intracerebral malignant tumors. Increasing evidence indicates an association between the immune signature and Grade II/III glioma prognosis. Thus, we aimed to develop an immune-related gene pair (IRGP) signature that can be used as a prognostic tool in Grade II/III glioma.Methods: The gene expression levels and clinical information of Grade II/III glioma patients were collected from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases. The TCGA data were randomly divided into a training cohort (n = 249) and a validation cohort (n = 162), and a CGGA dataset served as an external validation group (n = 605). IRGPs significantly associated with prognosis were selected by Cox regression. Gene set enrichment analysis and filtration were performed with the IRGPs.Results: Within a set of 1991 immune genes, 8 IRGPs including 15 unique genes that significantly affect survival constituted a gene signature. In the validation datasets, the IRGP signature significantly stratified patients with Grade II/III glioma into low- and high-risk groups (P < 0.001), and the IRGP index was found to be an independent prognostic factor through univariate and multivariate analyses (P < 0.05). Additionally, 26 functional pathways were identified through the intersection of Gene Set Enrichment Analysis (GSEA) and Gene Ontology (GO) enrichment analysis.Conclusion: The IRGP signature demonstrated good prognostic value for Grade II/III gliomas, which may provide new insights into individual treatment for glioma patients. The IRGPs might function through the identified 26 functional pathways.Keywords: glioma, prognosis, immune-related gene pairs, TCGA, CGGAZhang XPing SWang ALi CZhang RSong ZGao CWang FDove Medical Pressarticlegliomaprognosisimmune-related gene pairstcgacggaMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8611-8620 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glioma prognosis immune-related gene pairs tcga cgga Medicine (General) R5-920
spellingShingle	glioma prognosis immune-related gene pairs tcga cgga Medicine (General) R5-920 Zhang X Ping S Wang A Li C Zhang R Song Z Gao C Wang F Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma
description	Xu Zhang,1,&ast; Shuai Ping,2,&ast; Anni Wang,3 Can Li,4 Rui Zhang,5 Zimu Song,3 Caibin Gao,3 Feng Wang6 1Department of Neurosurgery, Baoding No.1 Central Hospital, Baoding, People’s Republic of China; 2Department of Orthopaedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 4Department of Neurosurgery, Chengdu Sixth People’s Hospital, Chengdu, People’s Republic of China; 5Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, People’s Republic of China; 6Department of Neurosurgery, People’s Hospital of Ningxia Hui Autonomous Region Yinchuan, Yinchuan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Feng Wang Email nxwwang@163.comBackground: Gliomas are prevalent primary intracerebral malignant tumors. Increasing evidence indicates an association between the immune signature and Grade II/III glioma prognosis. Thus, we aimed to develop an immune-related gene pair (IRGP) signature that can be used as a prognostic tool in Grade II/III glioma.Methods: The gene expression levels and clinical information of Grade II/III glioma patients were collected from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases. The TCGA data were randomly divided into a training cohort (n = 249) and a validation cohort (n = 162), and a CGGA dataset served as an external validation group (n = 605). IRGPs significantly associated with prognosis were selected by Cox regression. Gene set enrichment analysis and filtration were performed with the IRGPs.Results: Within a set of 1991 immune genes, 8 IRGPs including 15 unique genes that significantly affect survival constituted a gene signature. In the validation datasets, the IRGP signature significantly stratified patients with Grade II/III glioma into low- and high-risk groups (P < 0.001), and the IRGP index was found to be an independent prognostic factor through univariate and multivariate analyses (P < 0.05). Additionally, 26 functional pathways were identified through the intersection of Gene Set Enrichment Analysis (GSEA) and Gene Ontology (GO) enrichment analysis.Conclusion: The IRGP signature demonstrated good prognostic value for Grade II/III gliomas, which may provide new insights into individual treatment for glioma patients. The IRGPs might function through the identified 26 functional pathways.Keywords: glioma, prognosis, immune-related gene pairs, TCGA, CGGA
format	article
author	Zhang X Ping S Wang A Li C Zhang R Song Z Gao C Wang F
author_facet	Zhang X Ping S Wang A Li C Zhang R Song Z Gao C Wang F
author_sort	Zhang X
title	Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma
title_short	Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma
title_full	Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma
title_fullStr	Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma
title_full_unstemmed	Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma
title_sort	development and validation of an immune-related gene pairs signature in grade ii/iii glioma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/55106287be0e4f809cd6ecff8faa94cf
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Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma

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