Neural activity in the human anterior thalamus during natural vision

Abstract In natural vision humans and other primates explore environment by active sensing, using saccadic eye movements to relocate the fovea and sample different bits of information multiple times per second. Saccades induce a phase reset of ongoing neuronal oscillations in primary and higher-orde...

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Autores principales:	Marcin Leszczynski, Leila Chaieb, Tobias Staudigl, Simon Jonas Enkirch, Juergen Fell, Charles E. Schroeder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/551408da270344888da64bc8098ce486
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spelling	oai:doaj.org-article:551408da270344888da64bc8098ce4862021-12-02T19:04:19ZNeural activity in the human anterior thalamus during natural vision10.1038/s41598-021-96588-x2045-2322https://doaj.org/article/551408da270344888da64bc8098ce4862021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96588-xhttps://doaj.org/toc/2045-2322Abstract In natural vision humans and other primates explore environment by active sensing, using saccadic eye movements to relocate the fovea and sample different bits of information multiple times per second. Saccades induce a phase reset of ongoing neuronal oscillations in primary and higher-order visual cortices and in the medial temporal lobe. As a result, neuron ensembles are shifted to a common state at the time visual input propagates through the system (i.e., just after fixation). The extent of the brain’s circuitry that is modulated by saccades is not yet known. Here, we evaluate the possibility that saccadic phase reset impacts the anterior nuclei of the thalamus (ANT). Using recordings in the human thalamus of three surgical patients during natural vision, we found that saccades and visual stimulus onset both modulate neural activity, but with distinct field potential morphologies. Specifically, we found that fixation-locked field potentials had a component that preceded saccade onset. It was followed by an early negativity around 50 ms after fixation onset which is significantly faster than any response to visual stimulus presentation. The timing of these events suggests that the ANT is predictively modulated before the saccadic eye movement. We also found oscillatory phase concentration, peaking at 3–4 Hz, coincident with suppression of Broadband High-frequency Activity (BHA; 80–180 Hz), both locked to fixation onset supporting the idea that neural oscillations in these nuclei are reorganized to a low excitability state right after fixation onset. These findings show that during real-world natural visual exploration neural dynamics in the human ANT is influenced by visual and oculomotor events, which supports the idea that ANT, apart from their contribution to episodic memory, also play a role in natural vision.Marcin LeszczynskiLeila ChaiebTobias StaudiglSimon Jonas EnkirchJuergen FellCharles E. SchroederNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcin Leszczynski Leila Chaieb Tobias Staudigl Simon Jonas Enkirch Juergen Fell Charles E. Schroeder Neural activity in the human anterior thalamus during natural vision
description	Abstract In natural vision humans and other primates explore environment by active sensing, using saccadic eye movements to relocate the fovea and sample different bits of information multiple times per second. Saccades induce a phase reset of ongoing neuronal oscillations in primary and higher-order visual cortices and in the medial temporal lobe. As a result, neuron ensembles are shifted to a common state at the time visual input propagates through the system (i.e., just after fixation). The extent of the brain’s circuitry that is modulated by saccades is not yet known. Here, we evaluate the possibility that saccadic phase reset impacts the anterior nuclei of the thalamus (ANT). Using recordings in the human thalamus of three surgical patients during natural vision, we found that saccades and visual stimulus onset both modulate neural activity, but with distinct field potential morphologies. Specifically, we found that fixation-locked field potentials had a component that preceded saccade onset. It was followed by an early negativity around 50 ms after fixation onset which is significantly faster than any response to visual stimulus presentation. The timing of these events suggests that the ANT is predictively modulated before the saccadic eye movement. We also found oscillatory phase concentration, peaking at 3–4 Hz, coincident with suppression of Broadband High-frequency Activity (BHA; 80–180 Hz), both locked to fixation onset supporting the idea that neural oscillations in these nuclei are reorganized to a low excitability state right after fixation onset. These findings show that during real-world natural visual exploration neural dynamics in the human ANT is influenced by visual and oculomotor events, which supports the idea that ANT, apart from their contribution to episodic memory, also play a role in natural vision.
format	article
author	Marcin Leszczynski Leila Chaieb Tobias Staudigl Simon Jonas Enkirch Juergen Fell Charles E. Schroeder
author_facet	Marcin Leszczynski Leila Chaieb Tobias Staudigl Simon Jonas Enkirch Juergen Fell Charles E. Schroeder
author_sort	Marcin Leszczynski
title	Neural activity in the human anterior thalamus during natural vision
title_short	Neural activity in the human anterior thalamus during natural vision
title_full	Neural activity in the human anterior thalamus during natural vision
title_fullStr	Neural activity in the human anterior thalamus during natural vision
title_full_unstemmed	Neural activity in the human anterior thalamus during natural vision
title_sort	neural activity in the human anterior thalamus during natural vision
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/551408da270344888da64bc8098ce486
work_keys_str_mv	AT marcinleszczynski neuralactivityinthehumananteriorthalamusduringnaturalvision AT leilachaieb neuralactivityinthehumananteriorthalamusduringnaturalvision AT tobiasstaudigl neuralactivityinthehumananteriorthalamusduringnaturalvision AT simonjonasenkirch neuralactivityinthehumananteriorthalamusduringnaturalvision AT juergenfell neuralactivityinthehumananteriorthalamusduringnaturalvision AT charleseschroeder neuralactivityinthehumananteriorthalamusduringnaturalvision
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Neural activity in the human anterior thalamus during natural vision

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