Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.

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Autores principales:	Kevin Litchfield, Max Levy, Darshna Dudakia, Paula Proszek, Claire Shipley, Sander Basten, Elizabeth Rapley, D. Timothy Bishop, Alison Reid, Robert Huddart, Peter Broderick, David Gonzalez de Castro, Simon O'Connor, Rachel H. Giles, Richard S. Houlston, Clare Turnbull
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5514be44ed294c9ca7423b116df904dc
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spelling	oai:doaj.org-article:5514be44ed294c9ca7423b116df904dc2021-12-02T17:32:54ZRare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility10.1038/ncomms138402041-1723https://doaj.org/article/5514be44ed294c9ca7423b116df904dc2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13840https://doaj.org/toc/2041-1723There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.Kevin LitchfieldMax LevyDarshna DudakiaPaula ProszekClaire ShipleySander BastenElizabeth RapleyD. Timothy BishopAlison ReidRobert HuddartPeter BroderickDavid Gonzalez de CastroSimon O'ConnorRachel H. GilesRichard S. HoulstonClare TurnbullNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin Litchfield Max Levy Darshna Dudakia Paula Proszek Claire Shipley Sander Basten Elizabeth Rapley D. Timothy Bishop Alison Reid Robert Huddart Peter Broderick David Gonzalez de Castro Simon O'Connor Rachel H. Giles Richard S. Houlston Clare Turnbull Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
description	There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.
format	article
author	Kevin Litchfield Max Levy Darshna Dudakia Paula Proszek Claire Shipley Sander Basten Elizabeth Rapley D. Timothy Bishop Alison Reid Robert Huddart Peter Broderick David Gonzalez de Castro Simon O'Connor Rachel H. Giles Richard S. Houlston Clare Turnbull
author_facet	Kevin Litchfield Max Levy Darshna Dudakia Paula Proszek Claire Shipley Sander Basten Elizabeth Rapley D. Timothy Bishop Alison Reid Robert Huddart Peter Broderick David Gonzalez de Castro Simon O'Connor Rachel H. Giles Richard S. Houlston Clare Turnbull
author_sort	Kevin Litchfield
title	Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
title_short	Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
title_full	Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
title_fullStr	Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
title_full_unstemmed	Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
title_sort	rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5514be44ed294c9ca7423b116df904dc
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Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

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