Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel

Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel

The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, an...

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Autores principales: Marieke W. Veldkamp, Guillaume S. C. Geuzebroek, Antonius Baartscheer, Arie O. Verkerk, Cees A. Schumacher, Gedeon G. Suarez, Wouter R. Berger, Simona Casini, Shirley C. M. van Amersfoorth, Koen T. Scholman, Antoine H. G. Driessen, Charly N. W. Belterman, Antoni C. G. van Ginneken, Joris R. de Groot, Jacques M. T. de Bakker, Carol Ann Remme, Bas J. Boukens, Ruben Coronel
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/551537e643be4d3280a69b3581a50647
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spelling oai:doaj.org-article:551537e643be4d3280a69b3581a506472021-12-02T17:32:33ZNeurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel10.1038/s41467-018-06530-52041-1723https://doaj.org/article/551537e643be4d3280a69b3581a506472018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06530-5https://doaj.org/toc/2041-1723The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, and prevents atrial fibrillation.Marieke W. VeldkampGuillaume S. C. GeuzebroekAntonius BaartscheerArie O. VerkerkCees A. SchumacherGedeon G. SuarezWouter R. BergerSimona CasiniShirley C. M. van AmersfoorthKoen T. ScholmanAntoine H. G. DriessenCharly N. W. BeltermanAntoni C. G. van GinnekenJoris R. de GrootJacques M. T. de BakkerCarol Ann RemmeBas J. BoukensRuben CoronelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marieke W. Veldkamp
Guillaume S. C. Geuzebroek
Antonius Baartscheer
Arie O. Verkerk
Cees A. Schumacher
Gedeon G. Suarez
Wouter R. Berger
Simona Casini
Shirley C. M. van Amersfoorth
Koen T. Scholman
Antoine H. G. Driessen
Charly N. W. Belterman
Antoni C. G. van Ginneken
Joris R. de Groot
Jacques M. T. de Bakker
Carol Ann Remme
Bas J. Boukens
Ruben Coronel
Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
description The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, and prevents atrial fibrillation.
format article
author Marieke W. Veldkamp
Guillaume S. C. Geuzebroek
Antonius Baartscheer
Arie O. Verkerk
Cees A. Schumacher
Gedeon G. Suarez
Wouter R. Berger
Simona Casini
Shirley C. M. van Amersfoorth
Koen T. Scholman
Antoine H. G. Driessen
Charly N. W. Belterman
Antoni C. G. van Ginneken
Joris R. de Groot
Jacques M. T. de Bakker
Carol Ann Remme
Bas J. Boukens
Ruben Coronel
author_facet Marieke W. Veldkamp
Guillaume S. C. Geuzebroek
Antonius Baartscheer
Arie O. Verkerk
Cees A. Schumacher
Gedeon G. Suarez
Wouter R. Berger
Simona Casini
Shirley C. M. van Amersfoorth
Koen T. Scholman
Antoine H. G. Driessen
Charly N. W. Belterman
Antoni C. G. van Ginneken
Joris R. de Groot
Jacques M. T. de Bakker
Carol Ann Remme
Bas J. Boukens
Ruben Coronel
author_sort Marieke W. Veldkamp
title Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
title_short Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
title_full Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
title_fullStr Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
title_full_unstemmed Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
title_sort neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background k+ channel
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/551537e643be4d3280a69b3581a50647
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