Depression is associated with CD4 levels in people living with HIV in Ecuador

Background: HIV can cause neurotoxicity and neuronal apoptosis, hence the importance of neuropathogenesis mechanisms in HIV. People in AIDS phase with CD4 count under 250, may be at greater risk of suffering from depression. Objective: Evaluate whether there is a relationship between T-CD4 lymphocyt...

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Autores principales:	Alejandro Checa, Eliana Navas, Verónica Valencia, Jessica Alcívar
Formato:	article
Lenguaje:	EN
Publicado:	Permanyer 2021
Materias:	CD4. HIV. Depression. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5516321f63d24cc0806619d0cc716b27
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spelling	oai:doaj.org-article:5516321f63d24cc0806619d0cc716b272021-11-12T01:48:49ZDepression is associated with CD4 levels in people living with HIV in Ecuador10.24875/RMN.210000322604-6180https://doaj.org/article/5516321f63d24cc0806619d0cc716b272021-01-01T00:00:00Zhttps://www.revmexneurociencia.com/frame_esp.php?id=159https://doaj.org/toc/2604-6180Background: HIV can cause neurotoxicity and neuronal apoptosis, hence the importance of neuropathogenesis mechanisms in HIV. People in AIDS phase with CD4 count under 250, may be at greater risk of suffering from depression. Objective: Evaluate whether there is a relationship between T-CD4 lymphocyte count and depression in people living with HIV but have not started antiretroviral treatment. Method: This was a cross-sectional cohort study conducted between October 2020 and January 2021 in the HIV Unit of the Eugenio Espejo Hospital in Quito. A CD4 test was performed, and the Hamilton Depression Scale was used in patients after 1 month of being diagnosed with HIV but before receiving antiretroviral treatment. Results: A total of 108 subjects were recruited, mainly men (79.6%), of which 82.4% were between 18 and 45 years old. The subjects in the AIDS phase were 25% of which 92.6% presented depression (p = 0.000), it was noted that the older the age, the prevalence of depression increases (p = 0.007). As for the female sex, it seems to have a risk of practically double with respect to men of suffering from depression (p = 0.005). Conclusions: In our cohort study, at PLWH in Ecuador, patients in AIDS phase present a considerable risk of suffering from depression; at the same time, as the age increases, the probability of presenting depression is greater. As well as, female sex is a risk factor. Therefore, the follow-up of these patients is an essential part of care and treatment process. Alejandro ChecaEliana NavasVerónica ValenciaJessica AlcívarPermanyerarticleCD4. HIV. Depression.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENRevista Mexicana de Neurociencia, Vol 22, Iss 6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CD4. HIV. Depression. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	CD4. HIV. Depression. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Alejandro Checa Eliana Navas Verónica Valencia Jessica Alcívar Depression is associated with CD4 levels in people living with HIV in Ecuador
description	Background: HIV can cause neurotoxicity and neuronal apoptosis, hence the importance of neuropathogenesis mechanisms in HIV. People in AIDS phase with CD4 count under 250, may be at greater risk of suffering from depression. Objective: Evaluate whether there is a relationship between T-CD4 lymphocyte count and depression in people living with HIV but have not started antiretroviral treatment. Method: This was a cross-sectional cohort study conducted between October 2020 and January 2021 in the HIV Unit of the Eugenio Espejo Hospital in Quito. A CD4 test was performed, and the Hamilton Depression Scale was used in patients after 1 month of being diagnosed with HIV but before receiving antiretroviral treatment. Results: A total of 108 subjects were recruited, mainly men (79.6%), of which 82.4% were between 18 and 45 years old. The subjects in the AIDS phase were 25% of which 92.6% presented depression (p = 0.000), it was noted that the older the age, the prevalence of depression increases (p = 0.007). As for the female sex, it seems to have a risk of practically double with respect to men of suffering from depression (p = 0.005). Conclusions: In our cohort study, at PLWH in Ecuador, patients in AIDS phase present a considerable risk of suffering from depression; at the same time, as the age increases, the probability of presenting depression is greater. As well as, female sex is a risk factor. Therefore, the follow-up of these patients is an essential part of care and treatment process.
format	article
author	Alejandro Checa Eliana Navas Verónica Valencia Jessica Alcívar
author_facet	Alejandro Checa Eliana Navas Verónica Valencia Jessica Alcívar
author_sort	Alejandro Checa
title	Depression is associated with CD4 levels in people living with HIV in Ecuador
title_short	Depression is associated with CD4 levels in people living with HIV in Ecuador
title_full	Depression is associated with CD4 levels in people living with HIV in Ecuador
title_fullStr	Depression is associated with CD4 levels in people living with HIV in Ecuador
title_full_unstemmed	Depression is associated with CD4 levels in people living with HIV in Ecuador
title_sort	depression is associated with cd4 levels in people living with hiv in ecuador
publisher	Permanyer
publishDate	2021
url	https://doaj.org/article/5516321f63d24cc0806619d0cc716b27
work_keys_str_mv	AT alejandrocheca depressionisassociatedwithcd4levelsinpeoplelivingwithhivinecuador AT eliananavas depressionisassociatedwithcd4levelsinpeoplelivingwithhivinecuador AT veronicavalencia depressionisassociatedwithcd4levelsinpeoplelivingwithhivinecuador AT jessicaalcivar depressionisassociatedwithcd4levelsinpeoplelivingwithhivinecuador
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Depression is associated with CD4 levels in people living with HIV in Ecuador

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