Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy

DAPK2 is a calmodulin-regulated protein kinase implicated in autophagy regulation, but how physiological stress leads to its activation is yet unknown. Here, the authors show that the central metabolic sensor AMPK phosphorylates DAPK2 to promote autophagy in a calmodulin-independent mechanism.

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Autores principales:	Ruth Shiloh, Yuval Gilad, Yaara Ber, Miriam Eisenstein, Dina Aweida, Shani Bialik, Shenhav Cohen, Adi Kimchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/551c55a627344344abff89cae54e5c69
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spelling	oai:doaj.org-article:551c55a627344344abff89cae54e5c692021-12-02T15:34:06ZNon-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy10.1038/s41467-018-03907-42041-1723https://doaj.org/article/551c55a627344344abff89cae54e5c692018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03907-4https://doaj.org/toc/2041-1723DAPK2 is a calmodulin-regulated protein kinase implicated in autophagy regulation, but how physiological stress leads to its activation is yet unknown. Here, the authors show that the central metabolic sensor AMPK phosphorylates DAPK2 to promote autophagy in a calmodulin-independent mechanism.Ruth ShilohYuval GiladYaara BerMiriam EisensteinDina AweidaShani BialikShenhav CohenAdi KimchiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruth Shiloh Yuval Gilad Yaara Ber Miriam Eisenstein Dina Aweida Shani Bialik Shenhav Cohen Adi Kimchi Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
description	DAPK2 is a calmodulin-regulated protein kinase implicated in autophagy regulation, but how physiological stress leads to its activation is yet unknown. Here, the authors show that the central metabolic sensor AMPK phosphorylates DAPK2 to promote autophagy in a calmodulin-independent mechanism.
format	article
author	Ruth Shiloh Yuval Gilad Yaara Ber Miriam Eisenstein Dina Aweida Shani Bialik Shenhav Cohen Adi Kimchi
author_facet	Ruth Shiloh Yuval Gilad Yaara Ber Miriam Eisenstein Dina Aweida Shani Bialik Shenhav Cohen Adi Kimchi
author_sort	Ruth Shiloh
title	Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
title_short	Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
title_full	Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
title_fullStr	Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
title_full_unstemmed	Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
title_sort	non-canonical activation of dapk2 by ampk constitutes a new pathway linking metabolic stress to autophagy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/551c55a627344344abff89cae54e5c69
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Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy

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