Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
DAPK2 is a calmodulin-regulated protein kinase implicated in autophagy regulation, but how physiological stress leads to its activation is yet unknown. Here, the authors show that the central metabolic sensor AMPK phosphorylates DAPK2 to promote autophagy in a calmodulin-independent mechanism.
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Nature Portfolio
2018
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oai:doaj.org-article:551c55a627344344abff89cae54e5c692021-12-02T15:34:06ZNon-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy10.1038/s41467-018-03907-42041-1723https://doaj.org/article/551c55a627344344abff89cae54e5c692018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03907-4https://doaj.org/toc/2041-1723DAPK2 is a calmodulin-regulated protein kinase implicated in autophagy regulation, but how physiological stress leads to its activation is yet unknown. Here, the authors show that the central metabolic sensor AMPK phosphorylates DAPK2 to promote autophagy in a calmodulin-independent mechanism.Ruth ShilohYuval GiladYaara BerMiriam EisensteinDina AweidaShani BialikShenhav CohenAdi KimchiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Ruth Shiloh Yuval Gilad Yaara Ber Miriam Eisenstein Dina Aweida Shani Bialik Shenhav Cohen Adi Kimchi Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy |
description |
DAPK2 is a calmodulin-regulated protein kinase implicated in autophagy regulation, but how physiological stress leads to its activation is yet unknown. Here, the authors show that the central metabolic sensor AMPK phosphorylates DAPK2 to promote autophagy in a calmodulin-independent mechanism. |
format |
article |
author |
Ruth Shiloh Yuval Gilad Yaara Ber Miriam Eisenstein Dina Aweida Shani Bialik Shenhav Cohen Adi Kimchi |
author_facet |
Ruth Shiloh Yuval Gilad Yaara Ber Miriam Eisenstein Dina Aweida Shani Bialik Shenhav Cohen Adi Kimchi |
author_sort |
Ruth Shiloh |
title |
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy |
title_short |
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy |
title_full |
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy |
title_fullStr |
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy |
title_full_unstemmed |
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy |
title_sort |
non-canonical activation of dapk2 by ampk constitutes a new pathway linking metabolic stress to autophagy |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/551c55a627344344abff89cae54e5c69 |
work_keys_str_mv |
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_version_ |
1718386899406553088 |