Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models.

The accumulation of glomerular extracellular matrix (ECM) is one of the critical pathological characteristics of diabetic renal fibrosis. Fibronectin (FN) is an important constituent of ECM. Our previous studies indicate that the activation of the sphingosine kinase 1 (SphK1)-sphingosine 1- phosphat...

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Autores principales: Kaipeng Huang, Weihua Liu, Tian Lan, Xi Xie, Jing Peng, Juan Huang, Shaogui Wang, Xiaoyan Shen, Peiqing Liu, Heqing Huang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/552128c9f89b45d89efe6e105865f2a4
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