HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

Once DNA breaks occur, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other DNA repair factors to initiate the repair process. Here, the authors resolve the crystal structures of mouse and human HPF1, and human HPF1/PARP1 complex proving insights into PARP1 regulation.

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Autores principales:	Fa-Hui Sun, Peng Zhao, Nan Zhang, Lu-Lu Kong, Catherine C. L. Wong, Cai-Hong Yun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5521b4d0d2ee4c4d8454f7128bbf8047
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spelling	oai:doaj.org-article:5521b4d0d2ee4c4d8454f7128bbf80472021-12-02T14:21:24ZHPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones10.1038/s41467-021-21302-42041-1723https://doaj.org/article/5521b4d0d2ee4c4d8454f7128bbf80472021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21302-4https://doaj.org/toc/2041-1723Once DNA breaks occur, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other DNA repair factors to initiate the repair process. Here, the authors resolve the crystal structures of mouse and human HPF1, and human HPF1/PARP1 complex proving insights into PARP1 regulation.Fa-Hui SunPeng ZhaoNan ZhangLu-Lu KongCatherine C. L. WongCai-Hong YunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fa-Hui Sun Peng Zhao Nan Zhang Lu-Lu Kong Catherine C. L. Wong Cai-Hong Yun HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
description	Once DNA breaks occur, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other DNA repair factors to initiate the repair process. Here, the authors resolve the crystal structures of mouse and human HPF1, and human HPF1/PARP1 complex proving insights into PARP1 regulation.
format	article
author	Fa-Hui Sun Peng Zhao Nan Zhang Lu-Lu Kong Catherine C. L. Wong Cai-Hong Yun
author_facet	Fa-Hui Sun Peng Zhao Nan Zhang Lu-Lu Kong Catherine C. L. Wong Cai-Hong Yun
author_sort	Fa-Hui Sun
title	HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
title_short	HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
title_full	HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
title_fullStr	HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
title_full_unstemmed	HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
title_sort	hpf1 remodels the active site of parp1 to enable the serine adp-ribosylation of histones
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5521b4d0d2ee4c4d8454f7128bbf8047
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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

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