HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

Once DNA breaks occur, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other DNA repair factors to initiate the repair process. Here, the authors resolve the crystal structures of mouse and human HPF1, and human HPF1/PARP1 complex proving insights into PARP1 regulation.

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Autores principales: Fa-Hui Sun, Peng Zhao, Nan Zhang, Lu-Lu Kong, Catherine C. L. Wong, Cai-Hong Yun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/5521b4d0d2ee4c4d8454f7128bbf8047
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