The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is an important syndrome of liver failure that has a high risk of short-term mortality in patients with chronic liver disease. The development of ACLF is associated with proinflammatory precipitating events, such as infection, alcoholic hepatitis, and intense sy...
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2021
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oai:doaj.org-article:55268ce0888e497f8d9afc7bbc1897d32021-11-11T17:08:32ZThe Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure10.3390/ijms2221116801422-00671661-6596https://doaj.org/article/55268ce0888e497f8d9afc7bbc1897d32021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11680https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Acute-on-chronic liver failure (ACLF) is an important syndrome of liver failure that has a high risk of short-term mortality in patients with chronic liver disease. The development of ACLF is associated with proinflammatory precipitating events, such as infection, alcoholic hepatitis, and intense systemic inflammation. Recently, the role of the gut microbiome has increasingly emerged in human health and disease. Additionally, the gut microbiome might have a major role in the development of liver disease. In this review, we examine evidence to support the role of gut dysbiosis in cirrhosis and ACLF. Additionally, we explore the mechanism by which the gut microbiome contributes to the development of ACLF, with a focus on alcohol-induced liver disease.Sung-Eun KimJi Won ParkHyung Su KimMyoung-Kuk JangKi Tae SukDong Joon KimMDPI AGarticlecirrhosisgut microbiomealcoholic liver diseaseacute-on-chronic liver failureBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11680, p 11680 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
cirrhosis gut microbiome alcoholic liver disease acute-on-chronic liver failure Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
cirrhosis gut microbiome alcoholic liver disease acute-on-chronic liver failure Biology (General) QH301-705.5 Chemistry QD1-999 Sung-Eun Kim Ji Won Park Hyung Su Kim Myoung-Kuk Jang Ki Tae Suk Dong Joon Kim The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure |
| description |
Acute-on-chronic liver failure (ACLF) is an important syndrome of liver failure that has a high risk of short-term mortality in patients with chronic liver disease. The development of ACLF is associated with proinflammatory precipitating events, such as infection, alcoholic hepatitis, and intense systemic inflammation. Recently, the role of the gut microbiome has increasingly emerged in human health and disease. Additionally, the gut microbiome might have a major role in the development of liver disease. In this review, we examine evidence to support the role of gut dysbiosis in cirrhosis and ACLF. Additionally, we explore the mechanism by which the gut microbiome contributes to the development of ACLF, with a focus on alcohol-induced liver disease. |
| format |
article |
| author |
Sung-Eun Kim Ji Won Park Hyung Su Kim Myoung-Kuk Jang Ki Tae Suk Dong Joon Kim |
| author_facet |
Sung-Eun Kim Ji Won Park Hyung Su Kim Myoung-Kuk Jang Ki Tae Suk Dong Joon Kim |
| author_sort |
Sung-Eun Kim |
| title |
The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure |
| title_short |
The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure |
| title_full |
The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure |
| title_fullStr |
The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure |
| title_full_unstemmed |
The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure |
| title_sort |
role of gut dysbiosis in acute-on-chronic liver failure |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/55268ce0888e497f8d9afc7bbc1897d3 |
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