Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

Active enhancers are defined by the presence of post-translational modifications of histones. Here, the authors use these marks to identify enhancers recurrently activated in colorectal cancer and find that these enhancers turn on oncogenes and are associated with known risk loci for developing the...

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Autores principales: Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, Jennifer M. Luppino, Katreya Lovrenert, Cynthia F. Bartels, James J. Morrow, Stephen C. Mack, Gursimran Dhillon, Lydia Beard, Lois Myeroff, Matthew F. Kalady, Joseph Willis, James E. Bradner, Ruth A. Keri, Nathan A. Berger, Shondra M. Pruett-Miller, Sanford D. Markowitz, Peter C. Scacheri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5528fdc3208d403fa301effc0fea14f8
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spelling oai:doaj.org-article:5528fdc3208d403fa301effc0fea14f82021-12-02T16:51:52ZHotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome10.1038/ncomms144002041-1723https://doaj.org/article/5528fdc3208d403fa301effc0fea14f82017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14400https://doaj.org/toc/2041-1723Active enhancers are defined by the presence of post-translational modifications of histones. Here, the authors use these marks to identify enhancers recurrently activated in colorectal cancer and find that these enhancers turn on oncogenes and are associated with known risk loci for developing the disease.Andrea J. CohenAlina SaiakhovaOlivia CorradinJennifer M. LuppinoKatreya LovrenertCynthia F. BartelsJames J. MorrowStephen C. MackGursimran DhillonLydia BeardLois MyeroffMatthew F. KaladyJoseph WillisJames E. BradnerRuth A. KeriNathan A. BergerShondra M. Pruett-MillerSanford D. MarkowitzPeter C. ScacheriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andrea J. Cohen
Alina Saiakhova
Olivia Corradin
Jennifer M. Luppino
Katreya Lovrenert
Cynthia F. Bartels
James J. Morrow
Stephen C. Mack
Gursimran Dhillon
Lydia Beard
Lois Myeroff
Matthew F. Kalady
Joseph Willis
James E. Bradner
Ruth A. Keri
Nathan A. Berger
Shondra M. Pruett-Miller
Sanford D. Markowitz
Peter C. Scacheri
Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
description Active enhancers are defined by the presence of post-translational modifications of histones. Here, the authors use these marks to identify enhancers recurrently activated in colorectal cancer and find that these enhancers turn on oncogenes and are associated with known risk loci for developing the disease.
format article
author Andrea J. Cohen
Alina Saiakhova
Olivia Corradin
Jennifer M. Luppino
Katreya Lovrenert
Cynthia F. Bartels
James J. Morrow
Stephen C. Mack
Gursimran Dhillon
Lydia Beard
Lois Myeroff
Matthew F. Kalady
Joseph Willis
James E. Bradner
Ruth A. Keri
Nathan A. Berger
Shondra M. Pruett-Miller
Sanford D. Markowitz
Peter C. Scacheri
author_facet Andrea J. Cohen
Alina Saiakhova
Olivia Corradin
Jennifer M. Luppino
Katreya Lovrenert
Cynthia F. Bartels
James J. Morrow
Stephen C. Mack
Gursimran Dhillon
Lydia Beard
Lois Myeroff
Matthew F. Kalady
Joseph Willis
James E. Bradner
Ruth A. Keri
Nathan A. Berger
Shondra M. Pruett-Miller
Sanford D. Markowitz
Peter C. Scacheri
author_sort Andrea J. Cohen
title Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
title_short Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
title_full Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
title_fullStr Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
title_full_unstemmed Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
title_sort hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/5528fdc3208d403fa301effc0fea14f8
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