Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

Active enhancers are defined by the presence of post-translational modifications of histones. Here, the authors use these marks to identify enhancers recurrently activated in colorectal cancer and find that these enhancers turn on oncogenes and are associated with known risk loci for developing the...

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Main Authors: Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, Jennifer M. Luppino, Katreya Lovrenert, Cynthia F. Bartels, James J. Morrow, Stephen C. Mack, Gursimran Dhillon, Lydia Beard, Lois Myeroff, Matthew F. Kalady, Joseph Willis, James E. Bradner, Ruth A. Keri, Nathan A. Berger, Shondra M. Pruett-Miller, Sanford D. Markowitz, Peter C. Scacheri
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/5528fdc3208d403fa301effc0fea14f8
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https://doaj.org/article/5528fdc3208d403fa301effc0fea14f8

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