Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

PrediXcan is a widely used gene expression imputation method that links genetic variants to gene expression. Here, the authors develop EpiXcan which leverages epigenetic annotations to inform transcriptomic imputation and further use the obtained gene-trait associations for computational drug repurp...

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Autores principales:	Wen Zhang, Georgios Voloudakis, Veera M. Rajagopal, Ben Readhead, Joel T. Dudley, Eric E. Schadt, Johan L. M. Björkegren, Yungil Kim, John F. Fullard, Gabriel E. Hoffman, Panos Roussos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/552fe60fc84041fb94b634d3c217a163
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spelling	oai:doaj.org-article:552fe60fc84041fb94b634d3c217a1632021-12-02T17:01:29ZIntegrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits10.1038/s41467-019-11874-72041-1723https://doaj.org/article/552fe60fc84041fb94b634d3c217a1632019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11874-7https://doaj.org/toc/2041-1723PrediXcan is a widely used gene expression imputation method that links genetic variants to gene expression. Here, the authors develop EpiXcan which leverages epigenetic annotations to inform transcriptomic imputation and further use the obtained gene-trait associations for computational drug repurposing.Wen ZhangGeorgios VoloudakisVeera M. RajagopalBen ReadheadJoel T. DudleyEric E. SchadtJohan L. M. BjörkegrenYungil KimJohn F. FullardGabriel E. HoffmanPanos RoussosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen Zhang Georgios Voloudakis Veera M. Rajagopal Ben Readhead Joel T. Dudley Eric E. Schadt Johan L. M. Björkegren Yungil Kim John F. Fullard Gabriel E. Hoffman Panos Roussos Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
description	PrediXcan is a widely used gene expression imputation method that links genetic variants to gene expression. Here, the authors develop EpiXcan which leverages epigenetic annotations to inform transcriptomic imputation and further use the obtained gene-trait associations for computational drug repurposing.
format	article
author	Wen Zhang Georgios Voloudakis Veera M. Rajagopal Ben Readhead Joel T. Dudley Eric E. Schadt Johan L. M. Björkegren Yungil Kim John F. Fullard Gabriel E. Hoffman Panos Roussos
author_facet	Wen Zhang Georgios Voloudakis Veera M. Rajagopal Ben Readhead Joel T. Dudley Eric E. Schadt Johan L. M. Björkegren Yungil Kim John F. Fullard Gabriel E. Hoffman Panos Roussos
author_sort	Wen Zhang
title	Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
title_short	Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
title_full	Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
title_fullStr	Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
title_full_unstemmed	Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
title_sort	integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/552fe60fc84041fb94b634d3c217a163
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Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

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