PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3

PTEN mutations are frequent in glioblastoma and often are associated with therapeutic resistance. Here, the authors demonstrate that PTEN regulates gene expression at the chromatin level by interacting with the histone chaperone DAXX and H3.3, and that DAXX inhibition inhibits PTEN-deficient GBM gro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jorge A. Benitez, Jianhui Ma, Matteo D’Antonio, Antonia Boyer, Maria Fernanda Camargo, Ciro Zanca, Stephen Kelly, Alireza Khodadadi-Jamayran, Nathan M. Jameson, Michael Andersen, Hrvoje Miletic, Shahram Saberi, Kelly A. Frazer, Webster K. Cavenee, Frank B. Furnari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/552fe99f5f044c3ab87a7c0942b022b9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:552fe99f5f044c3ab87a7c0942b022b9
record_format	dspace
spelling	oai:doaj.org-article:552fe99f5f044c3ab87a7c0942b022b92021-12-02T14:40:33ZPTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.310.1038/ncomms152232041-1723https://doaj.org/article/552fe99f5f044c3ab87a7c0942b022b92017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15223https://doaj.org/toc/2041-1723PTEN mutations are frequent in glioblastoma and often are associated with therapeutic resistance. Here, the authors demonstrate that PTEN regulates gene expression at the chromatin level by interacting with the histone chaperone DAXX and H3.3, and that DAXX inhibition inhibits PTEN-deficient GBM growth in vivo.Jorge A. BenitezJianhui MaMatteo D’AntonioAntonia BoyerMaria Fernanda CamargoCiro ZancaStephen KellyAlireza Khodadadi-JamayranNathan M. JamesonMichael AndersenHrvoje MileticShahram SaberiKelly A. FrazerWebster K. CaveneeFrank B. FurnariNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jorge A. Benitez Jianhui Ma Matteo D’Antonio Antonia Boyer Maria Fernanda Camargo Ciro Zanca Stephen Kelly Alireza Khodadadi-Jamayran Nathan M. Jameson Michael Andersen Hrvoje Miletic Shahram Saberi Kelly A. Frazer Webster K. Cavenee Frank B. Furnari PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3
description	PTEN mutations are frequent in glioblastoma and often are associated with therapeutic resistance. Here, the authors demonstrate that PTEN regulates gene expression at the chromatin level by interacting with the histone chaperone DAXX and H3.3, and that DAXX inhibition inhibits PTEN-deficient GBM growth in vivo.
format	article
author	Jorge A. Benitez Jianhui Ma Matteo D’Antonio Antonia Boyer Maria Fernanda Camargo Ciro Zanca Stephen Kelly Alireza Khodadadi-Jamayran Nathan M. Jameson Michael Andersen Hrvoje Miletic Shahram Saberi Kelly A. Frazer Webster K. Cavenee Frank B. Furnari
author_facet	Jorge A. Benitez Jianhui Ma Matteo D’Antonio Antonia Boyer Maria Fernanda Camargo Ciro Zanca Stephen Kelly Alireza Khodadadi-Jamayran Nathan M. Jameson Michael Andersen Hrvoje Miletic Shahram Saberi Kelly A. Frazer Webster K. Cavenee Frank B. Furnari
author_sort	Jorge A. Benitez
title	PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3
title_short	PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3
title_full	PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3
title_fullStr	PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3
title_full_unstemmed	PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3
title_sort	pten regulates glioblastoma oncogenesis through chromatin-associated complexes of daxx and histone h3.3
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/552fe99f5f044c3ab87a7c0942b022b9
work_keys_str_mv	AT jorgeabenitez ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT jianhuima ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT matteodantonio ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT antoniaboyer ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT mariafernandacamargo ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT cirozanca ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT stephenkelly ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT alirezakhodadadijamayran ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT nathanmjameson ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT michaelandersen ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT hrvojemiletic ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT shahramsaberi ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT kellyafrazer ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT websterkcavenee ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33 AT frankbfurnari ptenregulatesglioblastomaoncogenesisthroughchromatinassociatedcomplexesofdaxxandhistoneh33
_version_	1718390238546493440

PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3

Ejemplares similares