Can exchange transfusion be replaced by double-LED phototherapy?

Phototherapy is a conventional treatment for neonatal jaundice and widely considered as a safe procedure. Recent developments in light-emitting diode (LED) phototherapy devices have made more effective treatments possible. Exchange transfusion (ET) is typically applied for cases of refractory severe...

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Autores principales:	Abe Shinya, Fujioka Kazumichi
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	neonatal jaundice bilirubin irradiance led Medicine R
Acceso en línea:	https://doaj.org/article/55307a600c4244a9929ef69f7e5d59cc
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spelling	oai:doaj.org-article:55307a600c4244a9929ef69f7e5d59cc2021-12-05T14:10:55ZCan exchange transfusion be replaced by double-LED phototherapy?2391-546310.1515/med-2021-0320https://doaj.org/article/55307a600c4244a9929ef69f7e5d59cc2021-07-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0320https://doaj.org/toc/2391-5463Phototherapy is a conventional treatment for neonatal jaundice and widely considered as a safe procedure. Recent developments in light-emitting diode (LED) phototherapy devices have made more effective treatments possible. Exchange transfusion (ET) is typically applied for cases of refractory severe hyperbilirubinemia despite its risk of various complications. Since the therapeutic effect of phototherapy is correlated with its irradiance, ET may be avoided by performing phototherapy with higher irradiation. Recently, we adopted double-LED phototherapy as a bridging treatment to ET to treat a case of severe hyperbilirubinemia. In this case, the continual increase of bilirubin levels was suppressed immediately after its administration, and ET was not required. Throughout the treatment, no complications or increase in oxidative stress was observed. In addition, neurodevelopment was appropriate for the patient’s age at the 1-year follow-up, and no findings of kernicterus, including physical and magnetic resonance imaging findings, were observed. We hypothesized that double-LED phototherapy may be a good treatment strategy to replace ET for infants with severe hyperbilirubinemia; however, further investigations regarding safety issues including acute and long-term complications are needed before clinical adaptation.Abe ShinyaFujioka KazumichiDe Gruyterarticleneonatal jaundicebilirubinirradianceledMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 992-996 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neonatal jaundice bilirubin irradiance led Medicine R
spellingShingle	neonatal jaundice bilirubin irradiance led Medicine R Abe Shinya Fujioka Kazumichi Can exchange transfusion be replaced by double-LED phototherapy?
description	Phototherapy is a conventional treatment for neonatal jaundice and widely considered as a safe procedure. Recent developments in light-emitting diode (LED) phototherapy devices have made more effective treatments possible. Exchange transfusion (ET) is typically applied for cases of refractory severe hyperbilirubinemia despite its risk of various complications. Since the therapeutic effect of phototherapy is correlated with its irradiance, ET may be avoided by performing phototherapy with higher irradiation. Recently, we adopted double-LED phototherapy as a bridging treatment to ET to treat a case of severe hyperbilirubinemia. In this case, the continual increase of bilirubin levels was suppressed immediately after its administration, and ET was not required. Throughout the treatment, no complications or increase in oxidative stress was observed. In addition, neurodevelopment was appropriate for the patient’s age at the 1-year follow-up, and no findings of kernicterus, including physical and magnetic resonance imaging findings, were observed. We hypothesized that double-LED phototherapy may be a good treatment strategy to replace ET for infants with severe hyperbilirubinemia; however, further investigations regarding safety issues including acute and long-term complications are needed before clinical adaptation.
format	article
author	Abe Shinya Fujioka Kazumichi
author_facet	Abe Shinya Fujioka Kazumichi
author_sort	Abe Shinya
title	Can exchange transfusion be replaced by double-LED phototherapy?
title_short	Can exchange transfusion be replaced by double-LED phototherapy?
title_full	Can exchange transfusion be replaced by double-LED phototherapy?
title_fullStr	Can exchange transfusion be replaced by double-LED phototherapy?
title_full_unstemmed	Can exchange transfusion be replaced by double-LED phototherapy?
title_sort	can exchange transfusion be replaced by double-led phototherapy?
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/55307a600c4244a9929ef69f7e5d59cc
work_keys_str_mv	AT abeshinya canexchangetransfusionbereplacedbydoubleledphototherapy AT fujiokakazumichi canexchangetransfusionbereplacedbydoubleledphototherapy
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Can exchange transfusion be replaced by double-LED phototherapy?

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