Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Chimeric antigen receptor (CAR) T cell anti-cancer therapies might result in toxic side effects. Here the authors present a strategy based on the modulation of CAR T cells via administration of a bispecific adapter that target them to cancer cells, resulting in diminished CAR-T cells toxicity and en...

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Autores principales:	Yong Gu Lee, Haiyan Chu, Yingjuan Lu, Christopher P. Leamon, Madduri Srinivasarao, Karson S. Putt, Philip S. Low
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/553694276e0c432681cac75ecb3328c9
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spelling	oai:doaj.org-article:553694276e0c432681cac75ecb3328c92021-12-02T17:32:54ZRegulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters10.1038/s41467-019-10565-72041-1723https://doaj.org/article/553694276e0c432681cac75ecb3328c92019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10565-7https://doaj.org/toc/2041-1723Chimeric antigen receptor (CAR) T cell anti-cancer therapies might result in toxic side effects. Here the authors present a strategy based on the modulation of CAR T cells via administration of a bispecific adapter that target them to cancer cells, resulting in diminished CAR-T cells toxicity and enhanced solid tumor eradication.Yong Gu LeeHaiyan ChuYingjuan LuChristopher P. LeamonMadduri SrinivasaraoKarson S. PuttPhilip S. LowNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong Gu Lee Haiyan Chu Yingjuan Lu Christopher P. Leamon Madduri Srinivasarao Karson S. Putt Philip S. Low Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
description	Chimeric antigen receptor (CAR) T cell anti-cancer therapies might result in toxic side effects. Here the authors present a strategy based on the modulation of CAR T cells via administration of a bispecific adapter that target them to cancer cells, resulting in diminished CAR-T cells toxicity and enhanced solid tumor eradication.
format	article
author	Yong Gu Lee Haiyan Chu Yingjuan Lu Christopher P. Leamon Madduri Srinivasarao Karson S. Putt Philip S. Low
author_facet	Yong Gu Lee Haiyan Chu Yingjuan Lu Christopher P. Leamon Madduri Srinivasarao Karson S. Putt Philip S. Low
author_sort	Yong Gu Lee
title	Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
title_short	Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
title_full	Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
title_fullStr	Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
title_full_unstemmed	Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
title_sort	regulation of car t cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/553694276e0c432681cac75ecb3328c9
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Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

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