Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach

Cancer is, globally, one of the main causes of death. Even though various therapies are available, they are still painful because of their adverse side effects. Available treatments frequently fail due to unpromising responses, resistance to classical anticancer drugs, radiation therapy, chemotherap...

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Autores principales:	Torki A. Zughaibi, Mohd Suhail, Mohammad Tarique, Shams Tabrez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Akt cancer flavonoids inhibitors mTOR PI3K Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5537802d0141462caa6746946b65402f
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spelling	oai:doaj.org-article:5537802d0141462caa6746946b65402f2021-11-25T17:56:50ZTargeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach10.3390/ijms2222124551422-00671661-6596https://doaj.org/article/5537802d0141462caa6746946b65402f2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12455https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cancer is, globally, one of the main causes of death. Even though various therapies are available, they are still painful because of their adverse side effects. Available treatments frequently fail due to unpromising responses, resistance to classical anticancer drugs, radiation therapy, chemotherapy, and low accessibility to tumor tissues. Developing novel strategies to minimize adverse side effects, improve chemotherapy sensitivity, and control cancer progression is needed. Many studies have suggested small dietary molecules as complementary treatments for cancer patients. Different components of herbal/edible plants, known as flavonoids, have recently garnered attention due to their broad biological properties (e.g., antioxidant, antiviral, antimicrobial, anti-inflammatory, anti-mutagenic, anticancer, hepatoprotective, and cardioprotective). These flavonoids have shown anticancer activity by affecting different signaling cascades. This article summarizes the key progress made in this area and discusses the role of flavonoids by specifically inhibiting the PI3K/Akt/mTOR pathway in various cancers.Torki A. ZughaibiMohd SuhailMohammad TariqueShams TabrezMDPI AGarticleAktcancerflavonoidsinhibitorsmTORPI3KBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12455, p 12455 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Akt cancer flavonoids inhibitors mTOR PI3K Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Akt cancer flavonoids inhibitors mTOR PI3K Biology (General) QH301-705.5 Chemistry QD1-999 Torki A. Zughaibi Mohd Suhail Mohammad Tarique Shams Tabrez Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
description	Cancer is, globally, one of the main causes of death. Even though various therapies are available, they are still painful because of their adverse side effects. Available treatments frequently fail due to unpromising responses, resistance to classical anticancer drugs, radiation therapy, chemotherapy, and low accessibility to tumor tissues. Developing novel strategies to minimize adverse side effects, improve chemotherapy sensitivity, and control cancer progression is needed. Many studies have suggested small dietary molecules as complementary treatments for cancer patients. Different components of herbal/edible plants, known as flavonoids, have recently garnered attention due to their broad biological properties (e.g., antioxidant, antiviral, antimicrobial, anti-inflammatory, anti-mutagenic, anticancer, hepatoprotective, and cardioprotective). These flavonoids have shown anticancer activity by affecting different signaling cascades. This article summarizes the key progress made in this area and discusses the role of flavonoids by specifically inhibiting the PI3K/Akt/mTOR pathway in various cancers.
format	article
author	Torki A. Zughaibi Mohd Suhail Mohammad Tarique Shams Tabrez
author_facet	Torki A. Zughaibi Mohd Suhail Mohammad Tarique Shams Tabrez
author_sort	Torki A. Zughaibi
title	Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
title_short	Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
title_full	Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
title_fullStr	Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
title_full_unstemmed	Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach
title_sort	targeting pi3k/akt/mtor pathway by different flavonoids: a cancer chemopreventive approach
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5537802d0141462caa6746946b65402f
work_keys_str_mv	AT torkiazughaibi targetingpi3kaktmtorpathwaybydifferentflavonoidsacancerchemopreventiveapproach AT mohdsuhail targetingpi3kaktmtorpathwaybydifferentflavonoidsacancerchemopreventiveapproach AT mohammadtarique targetingpi3kaktmtorpathwaybydifferentflavonoidsacancerchemopreventiveapproach AT shamstabrez targetingpi3kaktmtorpathwaybydifferentflavonoidsacancerchemopreventiveapproach
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Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach

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