Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity

Abstract This study aimed to investigate alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity, which was implemented through the random positioning machine, while different light conditions (normal photoperiod and constant dark) were set. Fruit flies of diffe...

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Autores principales:	Hongying Zhang, Yahong Wang, Ziyan Zhang, Lu Zhang, Chao Tang, Boqun Sun, Zhihao Jiang, Bo Ding, Peng Cai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/553822abee834421ab9b44bb5f9ca677
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spelling	oai:doaj.org-article:553822abee834421ab9b44bb5f9ca6772021-12-02T16:43:41ZAlterations in the activity and sleep of Drosophila melanogaster under simulated microgravity10.1038/s41526-021-00157-52373-8065https://doaj.org/article/553822abee834421ab9b44bb5f9ca6772021-07-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00157-5https://doaj.org/toc/2373-8065Abstract This study aimed to investigate alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity, which was implemented through the random positioning machine, while different light conditions (normal photoperiod and constant dark) were set. Fruit flies of different strains and sexes were treated for 3 days, and activity and sleep were monitored using the Drosophila Activity Monitoring System. After 3 days of treatment, fruit flies were sampled to detect the relative expression levels of the major clock genes and some neurotransmitter-related genes. The results showed that for the normal photoperiod (LD) condition, the activity increased and sleep decreased under simulated microgravity, while for the constant dark (DD) condition, the activity and sleep rhythms appeared disordered and the activity increased, thus decreasing the likelihood of waking up during the day. Light conditions, strains, and sexes, individually or in combination, had impacts on the simulated microgravity effects on behaviors. The clock genes and neurotransmitter-related genes had different degrees of response among sexes and strains, although the overall changes were slight. The results indicated that the normal photoperiod could ease the effects of simulated microgravity on fruit flies’ activity and sleep and possible unidentified pathways involved in the regulatory mechanism need further exploration. This study is expected to provide ideas and references for studying the effects of microgravity on space life science.Hongying ZhangYahong WangZiyan ZhangLu ZhangChao TangBoqun SunZhihao JiangBo DingPeng CaiNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Hongying Zhang Yahong Wang Ziyan Zhang Lu Zhang Chao Tang Boqun Sun Zhihao Jiang Bo Ding Peng Cai Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity
description	Abstract This study aimed to investigate alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity, which was implemented through the random positioning machine, while different light conditions (normal photoperiod and constant dark) were set. Fruit flies of different strains and sexes were treated for 3 days, and activity and sleep were monitored using the Drosophila Activity Monitoring System. After 3 days of treatment, fruit flies were sampled to detect the relative expression levels of the major clock genes and some neurotransmitter-related genes. The results showed that for the normal photoperiod (LD) condition, the activity increased and sleep decreased under simulated microgravity, while for the constant dark (DD) condition, the activity and sleep rhythms appeared disordered and the activity increased, thus decreasing the likelihood of waking up during the day. Light conditions, strains, and sexes, individually or in combination, had impacts on the simulated microgravity effects on behaviors. The clock genes and neurotransmitter-related genes had different degrees of response among sexes and strains, although the overall changes were slight. The results indicated that the normal photoperiod could ease the effects of simulated microgravity on fruit flies’ activity and sleep and possible unidentified pathways involved in the regulatory mechanism need further exploration. This study is expected to provide ideas and references for studying the effects of microgravity on space life science.
format	article
author	Hongying Zhang Yahong Wang Ziyan Zhang Lu Zhang Chao Tang Boqun Sun Zhihao Jiang Bo Ding Peng Cai
author_facet	Hongying Zhang Yahong Wang Ziyan Zhang Lu Zhang Chao Tang Boqun Sun Zhihao Jiang Bo Ding Peng Cai
author_sort	Hongying Zhang
title	Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity
title_short	Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity
title_full	Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity
title_fullStr	Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity
title_full_unstemmed	Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity
title_sort	alterations in the activity and sleep of drosophila melanogaster under simulated microgravity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/553822abee834421ab9b44bb5f9ca677
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Alterations in the activity and sleep of Drosophila melanogaster under simulated microgravity

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