Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study

Takahiko NagamineDivision of Psychiatric Internal Medicine, Seiwakai-Kitsunan Hospital, Suzenji, JapanAbstract: During treatment of acute-phase schizophrenia, attention needs to be given to physical as well as psychological symptoms. It is often difficult, however, to obtain information on physical...

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Autor principal:	Takahiko Nagamine
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/553a6ead8336488db954a5042df44462
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spelling	oai:doaj.org-article:553a6ead8336488db954a5042df444622021-12-02T04:19:37ZAbnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study1176-63281178-2021https://doaj.org/article/553a6ead8336488db954a5042df444622010-06-01T00:00:00Zhttp://www.dovepress.com/abnormal-laboratory-values-during-the-acute-and-recovery-phases-in-sch-a4569https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Takahiko NagamineDivision of Psychiatric Internal Medicine, Seiwakai-Kitsunan Hospital, Suzenji, JapanAbstract: During treatment of acute-phase schizophrenia, attention needs to be given to physical as well as psychological symptoms. It is often difficult, however, to obtain information on physical symptoms from patients with psychomotor excitation, and only laboratory examinations can provide objective data. The results of laboratory parameters measured in 68 patients with schizophrenia during psychomotor excitation and approximately 1 month later during the medicated recovery phase have been analyzed retrospectively. Abnormal laboratory values during psychomotor excitation were frequent. The most frequent (&ge;35% of patients) were increased white blood cell count, low serum potassium levels, high levels of fasting blood sugar, lactate dehydrogenase and uric acid. There were fewer abnormal values during the medicated recovery phase. The most frequent (&ge;25% of patients) were high serum levels of triglycerides, amylase, creatinine kinase, and low-density lipoprotein cholesterol. Abnormal triglyceride levels were found significantly more frequently in patients receiving olanzapine than those receiving risperidone. Abnormal values during the acute phase may be the result of excitation such as increased sympathetic tone and dehydration. Abnormal values during the recovery phase appeared to be related to the adverse metabolic effects of antipsychotic drugs. The frequency of these abnormal values was particularly high in patients receiving olanzapine alone or in combination with other medications.Keywords: schizophrenia, laboratory test values, acute phase, recovery phase, risperidone, olanzapine Takahiko NagamineDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 281-288 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Takahiko Nagamine Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study
description	Takahiko NagamineDivision of Psychiatric Internal Medicine, Seiwakai-Kitsunan Hospital, Suzenji, JapanAbstract: During treatment of acute-phase schizophrenia, attention needs to be given to physical as well as psychological symptoms. It is often difficult, however, to obtain information on physical symptoms from patients with psychomotor excitation, and only laboratory examinations can provide objective data. The results of laboratory parameters measured in 68 patients with schizophrenia during psychomotor excitation and approximately 1 month later during the medicated recovery phase have been analyzed retrospectively. Abnormal laboratory values during psychomotor excitation were frequent. The most frequent (&ge;35% of patients) were increased white blood cell count, low serum potassium levels, high levels of fasting blood sugar, lactate dehydrogenase and uric acid. There were fewer abnormal values during the medicated recovery phase. The most frequent (&ge;25% of patients) were high serum levels of triglycerides, amylase, creatinine kinase, and low-density lipoprotein cholesterol. Abnormal triglyceride levels were found significantly more frequently in patients receiving olanzapine than those receiving risperidone. Abnormal values during the acute phase may be the result of excitation such as increased sympathetic tone and dehydration. Abnormal values during the recovery phase appeared to be related to the adverse metabolic effects of antipsychotic drugs. The frequency of these abnormal values was particularly high in patients receiving olanzapine alone or in combination with other medications.Keywords: schizophrenia, laboratory test values, acute phase, recovery phase, risperidone, olanzapine
format	article
author	Takahiko Nagamine
author_facet	Takahiko Nagamine
author_sort	Takahiko Nagamine
title	Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study
title_short	Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study
title_full	Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study
title_fullStr	Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study
title_full_unstemmed	Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study
title_sort	abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/553a6ead8336488db954a5042df44462
work_keys_str_mv	AT takahikonagamine abnormallaboratoryvaluesduringtheacuteandrecoveryphasesinschizophrenicpatientsaretrospectivestudy
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Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study

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